https://scholars.lib.ntu.edu.tw/handle/123456789/384348
標題: | Investigation of the protective effects of taurine against alloxan-induced diabetic retinal changes via electroretinogram and retinal histology with New Zealand white rabbits | 作者: | Chiang, S.T.-H. Yeh, S.-M. YI-CHEN CHEN Lin, S.-L. Tseng, J.-K. |
公開日期: | 2014 | 卷: | 2014 | 來源出版物: | International Journal of Endocrinology | 摘要: | The purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits. Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induced by 100 mg/kg alloxan injection); Group III (diabetes and fed with 200 mg/kg taurine); and Group IV (diabetes and fed with 400 mg/kg taurine). The body weight and blood glucose levels of the rabbits were monitored weekly. The ERG was measured on weeks 5 and 15. Retinal histology was analyzed in the end of the experiment. Results revealed that a taurine supplement significantly ameliorates the alloxan-induced hyperglycemia and protects the retina from electrophysiological changes. Group II showed a significant (P<0.05) change in the mean scotopic b-wave amplitude when compared to that of Group I, whereas the diabetic rabbits treated with taurine (Group III and IV) were analogous to Group I. Histologically, the amount of Bipolar and M?ller cells showed no difference (P>0.05) between all groups and when compared with those of Group I. Our study provides solid evidences that taurine possesses an antidiabetic activity, reduced loss of body weight, and less electrophysiological changes of the diabetic retina. ? 2014 Samuel Tung-Hsing Chiang et al. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84934963510&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/384348 |
DOI: | 10.1155/2014/631549 | SDG/關鍵字: | alloxan; glucose; taurine; amplitude modulation; animal experiment; animal model; animal tissue; antidiabetic activity; Article; B wave; body weight; cell assay; controlled study; diabetic retinopathy; diet supplementation; disease control; drug response; electroretinogram; glucose blood level; histology; male; Mueller cell; nonhuman; priority journal; rabbit; retina bipolar ganglion cell; retinal histology |
顯示於: | 動物科學技術學系 |
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