A novel PPARgamma agonist monascin's potential application in diabetes prevention
Journal
Food and Function
Journal Volume
5
Journal Issue
7
Pages
1334-1340
Date Issued
2014
Author(s)
Abstract
Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products possess a number of functional secondary metabolites, including the anti-inflammatory pigments monascin and ankaflavin. Monascin has been shown to prevent or ameliorate several conditions, including hypercholesterolemia, hyperlipidemia, diabetes, and obesity. Recently, monascin has been shown to improve hyperglycemia, attenuate oxidative stress, inhibit insulin resistance, and suppress inflammatory cytokine production. In our recent study, we have found that monascin is a peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist. The PPARgamma agonist activity had been investigated and its exerted benefits are inhibition of inflammation in methylglyoxal (MG)-treated rats, prevention of pancreas impairment causing advanced glycation endproducts (AGEs), promotion of insulin expression in vivo and in vitro, and attenuated carboxymethyllysine (CML)-induced hepatic stellate cell (HSC) activation in the past several years. Moreover, our studies also demonstrated that monascin also activated nuclear factor-erythroid 2-related factor 2 (Nrf2) in pancreatic RIN-m5F cell line thereby invading methylglyoxal induced pancreas dysfunction. In this review, we focus on the chemo-preventive properties of monascin against metabolic syndrome through PPARgamma and Nrf2 pathways. This journal is ? the Partner Organisations 2014.
SDGs
Other Subjects
Cell culture; Advanced glycation end products; Cytokine production; Hepatic stellate cells; Hypercholesterolemia; Insulin expressions; Monascus-fermented products; Secondary metabolites; Traditional Chinese Medicine; Insulin; advanced glycation end product; ankaflavin; antidiabetic agent; antiinflammatory agent; antioxidant; fused heterocyclic rings; insulin; monascin; Nfe2l2 protein, rat; peroxisome proliferator activated receptor gamma; riboflavin derivative; transcription factor Nrf2; agonists; animal; chemistry; cytology; diabetes mellitus; drug effects; human; liver; metabolism; Monascus; pancreas; rat; Animals; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus; Flavins; Glycosylation End Products, Advanced; Heterocyclic Compounds, 3-Ring; Humans; Hypoglycemic Agents; Insulin; Liver; Monascus; NF-E2-Related Factor 2; Pancreas; PPAR gamma; Rats
Type
journal article