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  2. College of Bioresources and Agriculture / 生物資源暨農學院
  3. School of Veterinary Medicine / 獸醫專業學院
  4. Molecular and Comparative Pathobiology / 分子暨比較病理生物學研究所
  5. Porcine circovirus type 2 decreases the infection and replication of attenuated classical swine fever virus in porcine alveolar macrophages
 
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Porcine circovirus type 2 decreases the infection and replication of attenuated classical swine fever virus in porcine alveolar macrophages

Journal
Research in Veterinary Science
Journal Volume
96
Journal Issue
1
Pages
187-195
Date Issued
2014
Author(s)
Huang, Yu-Liang
VICTOR FEI PANG  
Deng, Ming-Chung
CHIA-YI CHANG  
CHIAN-REN JENG  
DOI
10.1016/j.rvsc.2013.11.020
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-84892516532&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/384512
Abstract
Recently, it has been noted that porcine circovirus type 2 (PCV2) infection adversely affects the protective efficacy of Lapinized Philippines Coronel (LPC) vaccine, an attenuated strain of classical swine fever virus (CSFV), in pigs. In order to investigate the possible mechanisms of the PCV2-derived interference, an in vitro model was established to study the interaction of LPC virus (LPCV) and PCV2 in porcine alveolar macrophages (AMs). The results showed that PCV2 reduced the LPCV infection in AMs and the levels of PCV2-derived interference were dose-dependent. The PCV2-derived interference also reduced the replication level of LPCV in AMs. The full-length PCV2 DNA and its fragment DNA C9 CpG-ODN were involved in the reduction of LPCV infection in AMs, whereas UV-inactivated PCV2 was not. In addition, a moderate negative correlation between the LPCV antigen-containing rate and IFN-γ production was observed, and had a dose-dependent trend with the level of PCV2-inoculation. The results of the present study may partially explain how PCV2 infection interferes with the efficacy of LPC vaccine. ? 2013 Elsevier Ltd.
Subjects
Alveolar macrophage; Classical swine fever virus; Lapinized Philippines Coronel; Porcine circovirus type 2
SDGs

[SDGs]SDG3

Other Subjects
alpha interferon; CpG oligodeoxynucleotide; gamma interferon; genomic DNA; interleukin 10; interleukin 8; Lapinized Philippines Coronel vaccine; transforming growth factor beta1; tumor necrosis factor alpha; unclassified drug; virus antigen; virus DNA; virus vaccine; animal cell; animal experiment; article; Circovirus; classical swine fever; concentration response; controlled study; correlational study; cytokine production; drug efficacy; in vitro study; lung alveolus macrophage; nonhuman; organismal interaction; Pestivirus; porcine circovirus type 2; sequence analysis; swine; ultraviolet radiation; vaccination; virus genome; virus inactivation; virus interference; virus replication; Classical swine fever virus; Porcine circovirus 2; Suidae; Sus; Alveolar macrophage; Classical swine fever virus; Lapinized Philippines Coronel; Porcine circovirus type 2; Animals; Circoviridae Infections; Circovirus; Classical Swine Fever; Classical swine fever virus; Cytokines; Dose-Response Relationship, Immunologic; Macrophages, Alveolar; Oligodeoxyribonucleotides; Real-Time Polymerase Chain Reaction; RNA, Viral; Specific Pathogen-Free Organisms; Swine; Viral Vaccines; Virus Replication
Type
journal article

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