https://scholars.lib.ntu.edu.tw/handle/123456789/384588
標題: | Surfactant-Modified nanoclay exhibits an antiviral activity with high potency and broad spectrum | 作者: | Liang, J.-J. Wei, J.-C. Lee, Y.-L. Hsu, S.-H. Lin, J.-J. Lin, Y.-L. SHAN-HUI HSU JIANG-JEN LIN |
公開日期: | 2014 | 卷: | 88 | 期: | 8 | 起(迄)頁: | 4218-4228 | 來源出版物: | Journal of Virology | 摘要: | Nanomaterials have the characteristics associated with high surface-to-volume ratios and have been explored for their antiviral activity. Despite some success, cytotoxicity has been an issue in nanomaterial-based antiviral strategies. We previously developed a novel method to fully exfoliate montmorillonite clay to generate the most fundamental units of nanoscale silicate platelet (NSP). We further modified NSP by capping with various surfactants and found that the surfactant-modified NSP (NSQ) was less cytotoxic. In this study, we tested the antiviral potentials of a series of natural-clay-derived nanomaterials. Among the derivatives, NSP modified with anionic sodium dodecyl sulfate (NSQc), but not the pristine clay, unmodified NSP, a silver nanoparticle- NSP hybrid, NSP modified with cationic n-octadecanylamine hydrochloride salt, or NSP modified with nonionic Triton X-100, significantly suppressed the plaque-forming ability of Japanese encephalitis virus (JEV) at noncytotoxic concentrations. NSQc also blocked infection with dengue virus (DEN) and influenza A virus. Regarding the antiviral mechanism, NSQc interfered with viral binding through electrostatic interaction, since its antiviral activity can be neutralized by Polybrene, a cationic polymer. Furthermore, NSQc reduced the lethality of JEV and DEN infection in mouse challenge models. Thus, the surfactantmodified exfoliated nanoclay NSQc may be a novel nanomaterial with broad and potent antiviral activity. ? 2014, American Society for Microbiology. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84896909316&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/384588 |
DOI: | 10.1128/JVI.03256-13 | SDG/關鍵字: | antivirus agent; dodecyl sulfate sodium; montmorillonite; n octadecanylamine hydrochloride salt; nanoclay; nanomaterial; nanoscale silicate platelet; silver nanoparticle; sodium chloride; surfactant; triton x 100; unclassified drug; animal cell; animal experiment; animal model; antiviral activity; article; binding affinity; binding site; controlled study; dengue; Dengue virus; drug determination; drug effect; drug potency; drug safety; drug screening; in vivo study; influenza A; Influenza virus; Japanese encephalitis; Japanese encephalitis virus; molecular dynamics; mouse; nanodevice; nonhuman; priority journal; virus attachment; virus identification; virus particle; Animals; Antiviral Agents; Bentonite; Dengue Virus; Encephalitis Virus, Japanese; Encephalitis, Japanese; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Nanostructures; Octoxynol; Surface-Active Agents; Virus Diseases |
顯示於: | 高分子科學與工程學研究所 |
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