https://scholars.lib.ntu.edu.tw/handle/123456789/385087
標題: | APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease | 作者: | Chang, Y.-L. Fennema-Notestine, C. Holl, D. McEvoy, L.K. Stricker, N.H. Salmon, D.P. Dale, A.M. Bondi, M.W. YU-LING CHANG |
關鍵字: | Alzheimer's disease; APOE genotype; Cognition; Longitudinal; Magnetic resonance imaging; Morphometry | 公開日期: | 2014 | 卷: | 10 | 期: | 3 | 起(迄)頁: | 336-348 | 來源出版物: | Alzheimer's and Dementia | 摘要: | Objective To determine (1) whether age-standardized cognitive declines and brain morphometric change differ between Young-Old patients with Alzheimer's disease (YOAD) and Very-Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E (APOE) genotype modifies these neuropsychological and morphometric changes. Methods Baseline and 12-month follow-up neuropsychological and morphometric measures were examined for healthy control subjects and patients with AD. The two AD groups were divided further into subgroups on the basis of the presence of at least one APOE ε4 allele. Results The YOAD group showed more severe deficits and steeper declines in cognition than the VOAD group. Moreover, the presence of an APOE ε4 allele had a more deleterious effect on the YOAD group than the VOAD group on cognition and brain structure both cross-sectionally and longitudinally. Conclusions Results underscore the importance of integrating an individual's age and genetic susceptibility - and their interaction - when examining neuropsychological and neuroimaging changes in the early stages of Alzheimer's disease. ? 2014 The Alzheimer's Association. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84899631915&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/385087 |
DOI: | 10.1016/j.jalz.2013.05.1763 | SDG/關鍵字: | apolipoprotein E; apolipoprotein E4; apolipoprotein E4; adult; aged; allele; Alzheimer disease; article; cognition; cognitive defect; controlled study; female; follow up; genetic polymorphism; genotype; human; major clinical study; male; middle aged; morphometrics; nuclear magnetic resonance imaging; priority journal; risk factor; temporal lobe; very elderly; age; Alzheimer disease; brain; cross-sectional study; genetic predisposition; genetics; longitudinal study; neuropsychological test; pathology; psychology; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Brain; Cross-Sectional Studies; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests |
顯示於: | 心理學系 |
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