Chemopreventative effects of tetrahydrocurcumin on human diseases
Journal
Food and Function
Journal Volume
5
Journal Issue
1
Pages
12-17
Date Issued
2014
Author(s)
Abstract
Chemoprevention is a relatively new and promising strategy to prevent human degenerative diseases, including cancer, and is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the progress of human diseases. Tetrahydrocurcumin (THC) is a major metabolite of curcumin (extracted from the roots of the Curcuma longa Linn). THC has been demonstrated to prevent oxidative stress and inflammation, to act against neurodegeneration, and to possess anti-cancer activity. In this review, we summarize the current knowledge and underlying molecular mechanisms of the chemopreventative activities of THC and its potential effects on the development of various human diseases. ? 2014 The Royal Society of Chemistry.
SDGs
Other Subjects
Metabolites; Anticancer activities; Chemopreventative; Chemoprevention; Degenerative disease; Molecular mechanism; Neurodegeneration; Potential effects; Tetrahydrocurcumin; Diseases; curcumin; drug derivative; plant extract; tetrahydrocurcumin; animal; Curcuma; diet therapy; human; metabolism; neoplasm; review; Animals; Curcuma; Curcumin; Diet Therapy; Humans; Neoplasms; Plant Extracts
Type
journal article