https://scholars.lib.ntu.edu.tw/handle/123456789/385146
Title: | 5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis | Authors: | Ma, N. Lai, C.-S. Chung, C.-H. Yang, J.-M. Hsu, K.-C. Chen, C.-Y. Chung, T.-S. Li, S. Ho, C.-T. Pan, M.-H. MIN-HSIUNG PAN |
Keywords: | 5-Demethyltangeretin; DMBA; Inflammation; Tangeretin; TPA | Issue Date: | 2014 | Journal Volume: | 11 | Journal Issue: | C | Start page/Pages: | 528-537 | Source: | Journal of Functional Foods | Abstract: | 5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this study, we investigated the anti-tumor promoting effect and underlying molecular mechanism of 5-DTAN on 7,12-dimethyl-benz(a)anthracene (DMBA)-induced and 12-. O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis. Application of 5-DTAN prior to each TPA-treatment was more effective than that of TAN on reducing the number, incidence and size of papillomas in DMBA-initiated mouse skin. Moreover, 5-DTAN suppressed cyclooxygenase-2 (COX-2) protein expression more strongly than TAN through interfering with phosphatidylinositiol 3-kinase (PI3K)/Akt signaling and further activation of transcription factor NF-κB. Taken together, these results revealed for the first time the in vivo chemopreventive efficacy of 5-DTAN on inhibition of skin carcinogenesis through promoting apoptosis and molecular interactions with residues of PI3K, COX-2, and AKT that may potentially serve as a novel functional agent capable of preventing inflammation-associated tumorigenesis. ? 2014 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84926421206&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/385146 |
DOI: | 10.1016/j.jff.2014.08.009 | SDG/Keyword: | Citrus [SDGs]SDG3 |
Appears in Collections: | 食品科技研究所 |
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