Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approaches
Journal
Drug Discovery Today
Journal Volume
19
Journal Issue
9
Pages
1402-1409
Date Issued
2014-09
Author(s)
Abstract
Gastrointestinal cancers are asymptomatic in early tumor development, leading to high mortality rates. Peri- or postoperative chemotherapy is a common strategy used to prolong the life expectancy of patients with these diseases. Understanding the molecular mechanisms by which anticancer drugs exert their effect is crucial to the development of anticancer therapies, especially when drug resistance occurs and an alternative drug is needed. By integrating high-throughput techniques and computational modeling to explore biological systems at different levels, from gene expressions to networks, systems biology approaches have been successfully applied in various fields of cancer research. In this review, we highlight chemotherapy studies that reveal potential signatures using microarray analysis, next-generation sequencing (NGS), proteomic and metabolomic approaches for the treatment of gastrointestinal cancers. ? 2014 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
1 acyl lysophosphatidylcholine; antineoplastic agent; bortezomib; fluorouracil; folinic acid; glutamic acid; growth factor; irinotecan; lipid; lysophosphatidylcholine; proline; proteasome; ubiquitin; unclassified drug; antineoplastic agent; cancer chemotherapy; cancer resistance; cell fusion; cell survival; chemosensitivity; digestive system cancer; DNA methylation; drug cytotoxicity; drug targeting; gene expression regulation; high throughput sequencing; human; lipid blood level; metabolomics; microarray analysis; nonhuman; phase 2 clinical trial (topic); protein synthesis; proteomics; pyrimidine synthesis; regulatory mechanism; Review; signal transduction; systems biology; computer simulation; drug design; drug resistance; Gastrointestinal Neoplasms; high throughput screening; molecularly targeted therapy; pathology; procedures; systems biology; Antineoplastic Agents; Computer Simulation; Drug Design; Drug Resistance, Neoplasm; Gastrointestinal Neoplasms; High-Throughput Screening Assays; Humans; Metabolomics; Microarray Analysis; Molecular Targeted Therapy; Proteomics; Systems Biology
Publisher
Elsevier Ltd.
Type
journal article