https://scholars.lib.ntu.edu.tw/handle/123456789/385323
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsieh, Y.-H. | en_US |
dc.contributor.author | CHEN-AN TSAI | en_US |
dc.contributor.author | Lin, C.-Y. | en_US |
dc.contributor.author | Chen, J.-H. | en_US |
dc.contributor.author | King, C.-C. | en_US |
dc.contributor.author | Chao, D.-Y. | en_US |
dc.contributor.author | Cheng, K.-F. | en_US |
dc.creator | Hsieh, Y.-H.;Tsai, C.-A.;Lin, C.-Y.;Chen, J.-H.;King, C.-C.;Chao, D.-Y.;Cheng, K.-F. | - |
dc.date.accessioned | 2018-09-10T14:54:24Z | - |
dc.date.available | 2018-09-10T14:54:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84893642948&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/385323 | - |
dc.description.abstract | Background: Studies indicate that asymptomatic infections do indeed occur frequently for both seasonal and pandemic influenza, accounting for about one-third of influenza infections. Studies carried out during the 2009 pH1N1 pandemic have found significant antibody response against seasonal H1N1 and H3N2 vaccine strains in schoolchildren receiving only pandemic H1N1 monovalent vaccine, yet reported either no symptoms or only mild symptoms.Methods: Serum samples of 255 schoolchildren, who had not received vaccination and had pre-season HI Ab serotiters <40, were collected from urban, rural areas and an isolated island in Taiwan during the 2005-2006 influenza season. Their hemagglutination inhibition antibody (HI Ab) serotiters against the 2005 A/New Caledonia/20/99 (H1N1) vaccine strain at pre-season and post-season were measured to determine the symptoms with the highest correlation with infection, as defined by 4-fold rise in HI titer. We estimate the asymptomatic ratio, or the proportion of asymptomatic infections, for schoolchildren during the 2005-6 influenza season when this vaccine strain was found to be antigenically related to the circulating H1N1 strain.Results: Fever has the highest correlation with the 2005-06 seasonal influenza A(H1N1) infection, followed by headache, cough, vomiting, and sore throat. Asymptomatic ratio for the schoolchildren is found to range between 55.6% (95% CI: 44.7-66.4)-77.9% (68.8-87.0) using different sets of predictive symptoms. Moreover, the asymptomatic ratio was 66.9% (56.6-77.2) when using US-CDC criterion of fever + (cough/sore throat), and 73.0 (63.3-82.8) when under Taiwan CDC definition of Fever + (cough or sore throat or nose) + ( headache or pain or fatigue).Conclusions: Asymptomatic ratio for children is found to be substantially higher than that of the general population in literature. In providing reasonable quantification of the asymptomatic infected children spreading pathogens to others in a seasonal epidemic or a pandemic, our estimates of symptomatic ratio of infected children has important clinical and public health implications. ? 2014 Hsieh et al.; licensee BioMed Central Ltd. | - |
dc.language | en | en |
dc.relation.ispartof | BMC Infectious Diseases | en_US |
dc.source | AH | - |
dc.subject | Asymptomatic infection; Asymptomatic ratio; H1N1; Seasonal influenza; Symptoms; Taiwan | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hemagglutination inhibiting antibody; influenza vaccine; virus antibody; antibody isolation; antibody titer; article; asymptomatic infection; blood analysis; child; coughing; disease association; fatigue; female; fever; headache; human; influenza A (H1N1); Influenza virus A H1N1; major clinical study; male; New Caledonia; pain; rhinorrhea; rural area; school child; seasonal influenza; sore throat; symptomatology; Taiwan; urban area; vomiting; blood; Cough; epidemic; fever; hemagglutination inhibition test; infection control; Influenza virus A H1N1; Influenza, Human; multivariate analysis; preventive health service; receiver operating characteristic; rural population; season; statistical model; urban population; Antibodies, Viral; Child; Communicable Disease Control; Cough; Epidemics; Female; Fever; Hemagglutination Inhibition Tests; Humans; Immunization Programs; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Logistic Models; Male; Multivariate Analysis; ROC Curve; Rural Population; Seasons; Taiwan; Urban Population | - |
dc.title | Asymptomatic ratio for seasonal H1N1 influenza infection among schoolchildren in Taiwan | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/1471-2334-14-80 | - |
dc.relation.journalvolume | 14 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Agronomy | - |
crisitem.author.dept | Master Program in Statistics | - |
crisitem.author.orcid | 0000-0002-7490-4331 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: Center for General Education | - |
顯示於: | 農藝學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。