https://scholars.lib.ntu.edu.tw/handle/123456789/385803
標題: | Bioactive cembranoids, sarcocrassocolides P-R, from the Dongsha Atoll soft coral Sarcophyton crassocaule | 作者: | Lin, W.-Y. Chen, B.-W. Huang, C.-Y. Wen, Z.-H. Sung, P.-J. Su, J.-H. CHANG-FENG DAI Sheu, J.-H. |
關鍵字: | Anti-inflammatory activity; Cytotoxic activity; Sarcophyton crassocaule; Soft coral | 公開日期: | 2014 | 卷: | 12 | 期: | 2 | 起(迄)頁: | 840-850 | 來源出版物: | Marine Drugs | 摘要: | New cembranoids, sarcocrassocolides P-R (1-3) and four known compounds (4-7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3-5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1-7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells. ? 2014 by the authors; licensee MDPI. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84896696806&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/385803 |
DOI: | 10.3390/md12020840 | SDG/關鍵字: | cembranoid; cyclooxygenase 2; doxorubicin; inducible nitric oxide synthase; lipopolysaccharide; sarcocrassocolide P; sarcocrassocolide Q; sarcocrassocolide R; unclassified drug; antiinflammatory activity; article; cancer cell culture; cell strain RAW264.7; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; in vitro study; macrophage; nonhuman; nuclear magnetic resonance spectroscopy; protein expression; Sarcophyton crassocaule; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Diterpenes; Humans; Lipopolysaccharides; Macrophages; Mice; Neoplasms; Nitric Oxide Synthase Type II |
顯示於: | 海洋研究所 |
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