https://scholars.lib.ntu.edu.tw/handle/123456789/385803
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin, W.-Y. | en_US |
dc.contributor.author | Chen, B.-W. | en_US |
dc.contributor.author | Huang, C.-Y. | en_US |
dc.contributor.author | Wen, Z.-H. | en_US |
dc.contributor.author | Sung, P.-J. | en_US |
dc.contributor.author | Su, J.-H. | en_US |
dc.contributor.author | CHANG-FENG DAI | en_US |
dc.contributor.author | Sheu, J.-H. | en_US |
dc.creator | Lin, W.-Y.; Chen, B.-W.; Huang, C.-Y.; Wen, Z.-H.; Sung, P.-J.; Su, J.-H.; Dai, C.-F.; Sheu, J.-H. | - |
dc.date.accessioned | 2018-09-10T14:55:14Z | - |
dc.date.available | 2018-09-10T14:55:14Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84896696806&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/385803 | - |
dc.description.abstract | New cembranoids, sarcocrassocolides P-R (1-3) and four known compounds (4-7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3-5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1-7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells. ? 2014 by the authors; licensee MDPI. | - |
dc.language | en | en |
dc.relation.ispartof | Marine Drugs | en_US |
dc.source | AH | - |
dc.subject | Anti-inflammatory activity; Cytotoxic activity; Sarcophyton crassocaule; Soft coral | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cembranoid; cyclooxygenase 2; doxorubicin; inducible nitric oxide synthase; lipopolysaccharide; sarcocrassocolide P; sarcocrassocolide Q; sarcocrassocolide R; unclassified drug; antiinflammatory activity; article; cancer cell culture; cell strain RAW264.7; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; in vitro study; macrophage; nonhuman; nuclear magnetic resonance spectroscopy; protein expression; Sarcophyton crassocaule; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Diterpenes; Humans; Lipopolysaccharides; Macrophages; Mice; Neoplasms; Nitric Oxide Synthase Type II | - |
dc.title | Bioactive cembranoids, sarcocrassocolides P-R, from the Dongsha Atoll soft coral Sarcophyton crassocaule | - |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/md12020840 | - |
dc.identifier.scopus | 2-s2.0-84896696806 | - |
dc.identifier.isi | WOS:000335745100013 | - |
dc.relation.pages | 840-850 | - |
dc.relation.journalvolume | 12 | - |
dc.relation.journalissue | 2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.orcid | 0000-0003-2242-5643 | - |
顯示於: | 海洋研究所 |
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