Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study
Journal
Supportive Care in Cancer
Journal Volume
23
Journal Issue
3
Pages
733-740
Date Issued
2014
Author(s)
HUEY-LING CHIANG
Abstract
Background: The comorbidity of depression with anxiety disorders is associated with poorer treatment outcomes, worse quality of life, poorer adherence to treatment, and greater suicide risk in cancer patients. Objective: To assess the risk of comorbid anxiety and depressive disorders after the diagnosis of esophageal cancer compared with a matched cohort by using the Taiwan National Health Insurance Research Database (NHIRD). Methods: We conducted a retrospective study of 28,454 patients (14,227 patients with esophageal cancer and 14,227 matched patients) who were selected from the NHIRD. Patients were observed for a maximum of 12?years to determine the incidence of new-onset anxiety and depressive disorders for which antidepressants had been prescribed. A Cox regression analysis was performed to identify the risk factors associated with anxiety and depressive disorders in esophageal cancer patients. Results: The cumulative incidence of anxiety and depressive disorders in the esophageal cancer patients was significantly higher than that in the matched cohort (P <.001). The adjusted hazard ratio (HR) was 2.24 (95?% confidence interval, CI = 1.95–2.56, P <.001) in the esophageal cancer cohort compared with the matched cohort. Independent risk factors for developing anxiety and depressive disorders among the patients with esophageal cancer included cirrhosis, cerebrovascular disease, and surgical treatment. Conclusion: Esophageal cancer may be a prominent risk factor for anxiety and depressive disorders. Based on our data, we suggest that attention should be focused on esophageal cancer patients with comorbid cirrhosis and cerebrovascular disease and those who have received surgical interventions. ? 2014, Springer-Verlag Berlin Heidelberg.
Subjects
Anxiety; Depression; Epidemiology; Esophageal neoplasms; Risk factors
SDGs
Other Subjects
adult; anxiety disorder; Article; autoimmune disease; cancer chemotherapy; cancer diagnosis; cancer patient; cancer radiotherapy; cancer surgery; cerebrovascular disease; chronic kidney disease; chronic obstructive lung disease; cohort analysis; comorbidity; controlled study; depression; diabetes mellitus; esophagus cancer; female; follow up; heart failure; heart muscle ischemia; human; hypertension; liver cirrhosis; major clinical study; male; population research; priority journal; retrospective study; risk assessment; risk factor; Taiwan; aged; Anxiety Disorders; case control study; Depressive Disorder; Esophageal Neoplasms; incidence; middle aged; psychology; quality of life; antidepressant agent; Aged; Antidepressive Agents; Anxiety Disorders; Case-Control Studies; Comorbidity; Depressive Disorder; Esophageal Neoplasms; Female; Humans; Incidence; Male; Middle Aged; Quality of Life; Retrospective Studies; Risk Factors; Taiwan
Type
journal article