https://scholars.lib.ntu.edu.tw/handle/123456789/387336
標題: | Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: An MRI evaluation | 作者: | Chang, H.-C. Juan, C.-J. Chiu, H.-C. Cheng, C.-C. Chiu, S.-C. Liu, Y.-J. Chung, H.-W. Hsu, H.-H. HSIAO-WEN CHUNG |
關鍵字: | Fat saturation; IDEAL fat-water separation; Parotid ADC measurement; Parotid fat content; PROPELLER | 公開日期: | 2014 | 卷: | 24 | 期: | 9 | 起(迄)頁: | 2069-2076 | 來源出版物: | European Radiology | 摘要: | Objectives: To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements. Methods: A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat-water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique. Results: Parotid fat content was larger in men than in women by about 10 percentage points (P<0.005), and positively associated with BMI and age for both genders (mostly with P<0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women (P<0.005), but showed no gender difference if measured using fat-saturated PROPELLER (P=0.840). The negative association between parotid ADC and age/BMI/fat (P<0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data. Conclusions: Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation. Key Points: ? Parotid fat content in healthy adults correlates positively with age and BMI. ? The rate of aging-related increase in fat contents is gender-dependent. ? Parotid ADC measurements are strongly influenced by fat saturation. ? 2014 European Society of Radiology. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84905912917&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/387336 |
DOI: | 10.1007/s00330-014-3265-z | SDG/關鍵字: | adipose tissue; adult; age; anatomy and histology; body mass; diffusion weighted imaging; female; human; male; middle aged; parotid gland; procedures; prospective study; reference value; sex difference; three dimensional imaging; very elderly; Adipose Tissue; Adult; Age Factors; Aged, 80 and over; Body Mass Index; Diffusion Magnetic Resonance Imaging; Female; Humans; Imaging, Three-Dimensional; Male; Middle Aged; Parotid Gland; Prospective Studies; Reference Values; Sex Factors |
顯示於: | 生醫電子與資訊學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。