https://scholars.lib.ntu.edu.tw/handle/123456789/389369
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YUNG-LING LEE | en |
dc.creator | Lin, Y.-T. ; Lee, Y.L. ; Jung, C.-R. ; Jaakkola, J.J.K. ; Hwang, B.-F. | - |
dc.date.accessioned | 2018-09-10T15:01:37Z | - |
dc.date.available | 2018-09-10T15:01:37Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84900418297&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/389369 | - |
dc.description.abstract | Background: Air pollution influences the development of limb defects in animals. There is little epidemiologic evidence on the effect of prenatal air pollution exposure on the risk of limb defects. Objective: To assess the relations between exposure to ambient air pollutants and the risk of limb defects. Methods: We conducted a matched-pairs case-control study in Taiwan from 2001 through 2007. The case group consisted of 1687 limb defects and the control group was density-sampling matched one to ten based on the month and year of conception from 1510,064 live singleton newborns in 2001-2007. Adjusted conditional logistic regression models were used to estimate odds ratios per 10ppb change for O3, NO2, 1ppb change for SO2, 10?g/m3 change for PM10, and 100ppb change for CO during the first trimester and first three gestational months. Results: Of the specific limb defects, reduction deformities of limbs (adjusted OR=1.024, 95% CI: 1.000, 1.048) was associated with a 1ppb increase in SO2 during weeks of 9-12 of gestation as well as the first trimester. Reduction deformities of limbs was also associated with a 10ppb increase in O3 during weeks of 1-4 of gestation (adjusted OR=1.391, 95% CI: 1.064, 1.818) among preterm births. Conclusion: The present study provides evidence that exposure to outdoor air SO2 during the first trimester of pregnancy may increase the risk of limb defects. Exposure to O3 was associated with reduction deformities of limbs among preterm births. Similar levels of SO2 and O3 are encountered globally by large numbers of pregnant women. ? 2014. | - |
dc.language | en | en |
dc.relation.ispartof | Environmental Research | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | Air pollution; Children; Limb defects; Ozone; Sulfur dioxide | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | fossil fuel; ambient air; animal; atmospheric pollution; health risk; limb; pollutant; pollution exposure; pregnancy; air pollutant; air pollution; article; case control study; controlled study; exhaust gas; female; gestational age; human; infant; limb defect; limb deformity; major clinical study; male; photooxidation; polydactyly; premature labor; prematurity; priority journal; Taiwan; Air pollution; Children; Limb defects; Ozone; Sulfur dioxide; Adult; Air Pollutants; Air Pollution; Case-Control Studies; Female; Gestational Age; Humans; Infant, Newborn; Limb Deformities, Congenital; Male; Maternal Exposure; Ozone; Pregnancy; Sex Factors; Sulfur Dioxide; Young Adult | - |
dc.title | Air pollution and limb defects: A matched-pairs case-control study in Taiwan | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.envres.2014.04.028 | - |
dc.relation.pages | 273-280 | - |
dc.relation.journalvolume | 132 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0002-2234-9479 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
顯示於: | 流行病學與預防醫學研究所 |
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