https://scholars.lib.ntu.edu.tw/handle/123456789/390094
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chiu, Chen-Yuan | en |
dc.contributor.author | SHING-HWA LIU | en |
dc.contributor.author | Chan, Im-Lam | en |
dc.contributor.author | Yang, Tsung-Han | en |
dc.contributor.author | Liu, Shing-Hwa | en |
dc.contributor.author | Chiang, Meng-Tsan | en |
dc.creator | Chiu, Chen-Yuan;Chan, Im-Lam;Yang, Tsung-Han;Liu, Shing-Hwa;Chiang, Meng-Tsan | - |
dc.date.accessioned | 2018-09-10T15:17:32Z | - |
dc.date.available | 2018-09-10T15:17:32Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84926156171&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/390094 | - |
dc.description.abstract | This study investigated the role of chitosan in lipogenesis in high-fat diet-induced obese rats. The lipogenesis-associated genes and their upstream regulatory proteins were explored. Diet supplementation of chitosan efficiently decreased the increased weights in body, livers, and adipose tissues in high-fat diet-fed rats. Chitosan supplementation significantly raised the lipolysis rate; attenuated the adipocyte hypertrophy, triglyceride accumulation, and lipoprotein lipase activity in epididymal adipose tissues; and decreased hepatic enzyme activities of lipid biosynthesis. Chitosan supplementation significantly activated adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and attenuated high-fat diet-induced protein expressions of lipogenic transcription factors (PPAR-γ and SREBP1c) in livers and adipose tissues. Moreover, chitosan supplementation significantly inhibited the expressions of downstream lipogenic genes (FAS, HMGCR, FATP1, and FABP4) in livers and adipose tissues of high-fat diet-fed rats. These results demonstrate for the first time that chitosan supplementation alleviates high-fat diet-enhanced lipogenesis in rats via AMPK activation and lipogenesis-associated gene inhibition. ? 2015 American Chemical Society. | - |
dc.language | en | en |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | en_US |
dc.source | AH | - |
dc.subject | AMP-activated protein kinase; chitosan; gene expression; high-fat diet; lipogenesis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Biochemistry; Chemical activation; Chitin; Chitosan; Enzyme activity; Enzymes; Genes; Histology; Nutrition; Proteins; Rats; Tissue; Transcription; Activated proteins; Adenosine monophosphate; Adipocyte hypertrophy; AMP-activated protein kinase; High-fat diet; Lipogenesis; Lipoprotein lipase; Regulatory protein; Gene expression; Rattus; chitosan; FABP4 protein, rat; fatty acid binding protein; hydroxymethylglutaryl coenzyme A reductase kinase; peroxisome proliferator activated receptor gamma; sterol regulatory element binding protein 1; adipose tissue; adverse effects; analysis; animal; diet supplementation; drug effects; enzyme activation; enzymology; gene expression; genetics; human; lipid diet; lipogenesis; liver; male; metabolism; obesity; pathophysiology; rat; Sprague Dawley rat; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Chitosan; Diet, High-Fat; Dietary Supplements; Enzyme Activation; Fatty Acid-Binding Proteins; Gene Expression; Humans; Lipogenesis; Liver; Male; Obesity; PPAR gamma; Rats; Rats, Sprague-Dawley; Sterol Regulatory Element Binding Protein 1 | - |
dc.title | Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acs.jafc.5b00198 | - |
dc.relation.pages | 2979-2988 | - |
dc.relation.journalvolume | 63 | - |
dc.relation.journalissue | 11 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Institute of Food Safety and Health | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.orcid | 0000-0002-9976-1197 | - |
crisitem.author.orcid | 0000-0002-9976-1197 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 毒理學研究所 |
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