|Title:||Rosiglitazone may reduce non-melanoma skin cancer risk in Taiwanese||Authors:||CHIN-HSIAO TSENG||Issue Date:||2015||Journal Volume:||15||Journal Issue:||1||Source:||BMC Cancer||Abstract:||
Background: Whether rosiglitazone may affect the risk of non-melanoma skin cancer (NMSC) has not been investigated. Methods: The reimbursement databases of all Taiwanese diabetic patients from 1996 to 2009 were retrieved from the National Health Insurance. An entry date was set at 1 January 2006 and a total of 886418 patients with type 2 diabetes were followed up for NMSC incidence until the end of 2009. Incidences for ever-users, never-users and subgroups of rosiglitazone exposure (using tertile cutoffs of duration of therapy and cumulative dose) were calculated and hazard ratios estimated by Cox regression. Additional models were created as sensitivity analyses. Results: There were 103097 ever-users and 783321 never-users, respective numbers of incident NMSC 250 (0.24%) and 2084 (0.27%), and respective incidence 68.90 and 76.77 per 100000 person-years. Although the overall hazard ratio was not significant in the unadjusted, age-sex-adjusted or fully adjusted model, the risk was significantly lower in the third tertile of duration of therapy and cumulative dose, with significant P for trends. The fully adjusted hazard ratio (95% confidence interval) for a duration of therapy >13.77 months and a cumulative dose of >1752 mg was 0.723 (0.566, 0.923) and 0.783 (0.618, 0.993), respectively. The findings were supported by various sensitivity analyses. Conclusions: Rosiglitazone may reduce the risk of NMSC, but further confirmation is required. ? Tseng; licensee BioMed Central.
|DOI:||10.1186/s12885-015-1057-8||metadata.dc.subject.other:||acarbose; insulin; metformin; rosiglitazone; sulfonylurea; 2,4 thiazolidinedione derivative; antidiabetic agent; rosiglitazone; adult; age distribution; aged; Article; cancer incidence; cancer risk; controlled study; diabetic patient; drug exposure; female; follow up; hazard ratio; human; information retrieval; major clinical study; male; national health insurance; non insulin dependent diabetes mellitus; non melanoma skin cancer; risk reduction; sensitivity analysis; sex difference; Taiwanese; treatment duration; comorbidity; factual database; incidence; middle aged; proportional hazards model; retrospective study; risk; Skin Neoplasms; Taiwan; very elderly; young adult; Adult; Aged; Aged, 80 and over; Comorbidity; Databases, Factual; Female; Humans; Hypoglycemic Agents; Incidence; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk; Skin Neoplasms; Taiwan; Thiazolidinediones; Young Adult
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