https://scholars.lib.ntu.edu.tw/handle/123456789/390411
標題: | Selecting probiotics with the abilities of enhancing GLP-1 to mitigate the progression of type 1 diabetes in vitro and in vivo | 作者: | Wei, S.-H. Chen, Y.-P. Chen, M.-J. MING-JU CHEN |
關鍵字: | GLP-1; Hyperglycaemia; Probiotics; Type 1 diabetes | 公開日期: | 2015 | 卷: | 18 | 起(迄)頁: | 473-486 | 來源出版物: | Journal of Functional Foods | 摘要: | We hypothesized that probiotics can stimulate enteroendocrine cells to secret glucagon-like peptide-1 (GLP-1) to mitigate the development of type 1 diabetes (T1D). We thus first established a novel screening platform by coculturing lactic acid bacteria with murine enteroendocrine STC-1 cells. Two strains, Lactobacillus kefiranofaciens M (denoted as Strain M) and Lactobacillus kefiri K (denoted as Strain K), were selected according to their capacity to enhance GLP-1 secretion. Administering Strain M and Strain K could alleviate the progression of T1D symptoms in streptozotocin-induced T1D mice model. This T1D-alleviating effect of the selected strains might involve stimulating the secretion of GLP-1, inhibiting the proinflammatory and inflammatory cytokines, elevating the production of IL-10, and modifying the intestinal microbiota. The possible mechanisms that induce Lb. kefiranofaciens M and Lb. kefiri K to stimulate GLP-1 must be further investigated. ? 2015 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84942525762&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/390411 |
DOI: | 10.1016/j.jff.2015.08.016 |
顯示於: | 動物科學技術學系 |
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