https://scholars.lib.ntu.edu.tw/handle/123456789/390997
標題: | A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses | 作者: | WEI-TSO CHIA | 關鍵字: | Antibiotic therapy; Combination therapy; Hyperthermia; In situ drug delivery; Photothermal response system | 公開日期: | 2015 | 卷: | 199 | 起(迄)頁: | 53-62 | 來源出版物: | Journal of Controlled Release | 摘要: | Eradicating subcutaneous bacterial infections remains a significant challenge. This work reports an injectable system of hollow microspheres (HMs) that can rapidly produce localized heat activated by near-infrared (NIR) light and control the release of an antibiotic via a "molecular switch" in their polymer shells, as a combination strategy for treating subcutaneous abscesses. The HMs have a shell of poly(d,l-lactic-co-glycolic acid) (PLGA) and an aqueous core that is comprised of vancomycin (Van) and polypyrrole nanoparticles (PPy NPs), which are photothermal agents. Experimental results demonstrate that the micro-HMs ensure efficiently the spatial stabilization of their encapsulated Van and PPy NPs at the injection site in mice with subcutaneous abscesses. Without NIR irradiation, the HMs elute a negligible drug concentration, but release substantially more when exposed to NIR light, suggesting that this system is suitable as a photothermally-responsive drug delivery system. The combination of photothermally-induced hyperthermia and antibiotic therapy with HMs increases cytotoxicity for bacteria in abscesses, to an extent that is greater than the sum of the two treatments alone, demonstrating a synergistic effect. This treatment platform may find other clinical applications, especially for localized hyperthermia-based cancer therapy. ? 2014 Elsevier B.V. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84918813052&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/390997 |
DOI: | 10.1016/j.jconrel.2014.12.011 | SDG/關鍵字: | Antibiotics; Drug delivery; Infrared devices; Polypyrroles; Antibiotic therapy; Bacterial infections; Clinical application; Combination strategies; Combination therapy; Hyperthermia; Photothermal response; Poly(d ,l lactic co glycolic acid) (PLGA); Hyperthermia therapy; nanocarrier; polyglactin; polypyrrole; vancomycin; antiinfective agent; lactic acid; microsphere; nanoparticle; polyglycolic acid; polylactic acid-polyglycolic acid copolymer; pyrrole derivative; vancomycin; animal experiment; animal model; animal tissue; antibacterial activity; antibiotic therapy; Article; bactericidal activity; chemical reaction; controlled study; drug cytotoxicity; drug distribution; drug release; hyperthermia; light scattering; methicillin resistant Staphylococcus aureus infection; molecular switch; mouse; nanoencapsulation; nonhuman; skin abscess; abscess; animal; Bagg albino mouse; drug delivery system; drug effects; heat; infrared radiation; methicillin resistant Staphylococcus aureus; photochemistry; Skin Diseases; subcutaneous drug administration; tissue distribution; wound healing; Abscess; Animals; Anti-Bacterial Agents; Drug Delivery Systems; Hot Temperature; Infrared Rays; Injections, Subcutaneous; Lactic Acid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microspheres; Nanoparticles; Photochemistry; Polyglycolic Acid; Pyrroles; Skin Diseases; Tissue Distribution; Vancomycin; Wound Healing |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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