Circadian systems biology in Metazoa
Journal
Briefings in Bioinformatics
Journal Volume
16
Journal Issue
6
Pages
1008–1024
Date Issued
2015-11
Author(s)
Abstract
Systems biology, which can be defined as integrative biology, comprisesmultistage processes that can be used to under- stand components of complex biological systems of living organisms and provides hierarchical information to decoding life. Using systems biology approaches such as genomics, transcriptomics and proteomics, it is now possible to delineate more complicated interactions between circadian control systems and diseases. The circadian rhythmis a multiscale phenomenon existing within the body that infiuences numerous physiological activities such as changes in gene expres- sion, protein turnover, metabolism and human behavior. In this review, we describe the relationships between the circadian control systemand its related genes or proteins, and circadian rhythmdisorders in systems biology studies. To maintain andmodulate circadian oscillation, cells possess elaborative feedback loops composed of circadian core proteins that regulate the expression of other genes through their transcriptional activities. The disruption of these rhythms has been reported to be associated with diseases such as arrhythmia, obesity, insulin resistance, carcinogenesis and disruptions in natural oscillations in the control of cell growth. This review demonstrates that lifestyle is considered as a fundamental factor thatmodifies circadian rhythm, and the development of dysfunctions and diseases could be regulated by an underlying expression network withmultiple circadian-associated signals. ? The Author 2015. Published by Oxford University Press.
Subjects
Circadian rhythm; Genomics; Proteomics; Systems biology; Transcriptomics
SDGs
Other Subjects
animal; circadian rhythm; systems biology; Animals; Circadian Rhythm; Systems Biology
Publisher
Oxford University Press
Type
journal article