Encapsulation of palladium porphyrin photosensitizer in layered metal oxide nanoparticles for photodynamic therapy against skin melanoma
Journal
Science and Technology of Advanced Materials
Journal Volume
16
Journal Issue
5
Date Issued
2015
Author(s)
Abstract
We designed a biodegradable nanocarrier of layered double hydroxide (LDH) for photodynamic therapy (PDT) based on the intercalation of a palladium porphyrin photosensitizer (PdTCPP) in the gallery of LDH for melanoma theragnosis. Physical and chemical characterizations have demonstrated the photosensitizer was stable in the layered structures. In addition, the synthesized nanocomposites rendered extremely efficacious therapy in the B16F10 melanoma cell line by improving the solubility of the hydrophobic PdTCPP photosensitizer. The detection of singlet oxygen generation under irradiation at the excitation wavelength of a 532 nm laser was indeed impressive. Furthermore, the in vivo results using a tumour xenograft model in mice indicated the apparent absence of body weight loss and relative organ weight variation to the liver and kidney demonstrated that the nanocomposites were biosafe with a significant reduction in tumour volume for the anti-cancer efficacy of PDT. This drug delivery system using the nanoparticle-photosensitizer hybrid has great potential in melanoma theragnosis. ? 2015 National Institute for Materials Science.
Subjects
layered double hydroxide; nanoparticles; photodynamic therapy
SDGs
Other Subjects
Cell culture; Dermatology; Enzyme inhibition; Gas generators; Laser excitation; Metal nanoparticles; Metals; Nanocomposites; Nanoparticles; Oncology; Palladium; Photosensitizers; Porphyrins; Tumors; B16f10 melanoma cells; Chemical characterization; Drug delivery system; Excitation wavelength; Layered double hydroxides; Metal oxide nanoparticles; Photodynamic therapy (PDT); Singlet oxygen generation; Photodynamic therapy
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
Encapsulation of palladium porphyrin photosens.pdf
Size
2.35 MB
Format
Adobe PDF
Checksum
(MD5):1630e41ad74c6b146188fc8ba96f7c3e