https://scholars.lib.ntu.edu.tw/handle/123456789/391673
標題: | Glaucumolides A and B, Biscembranoids with New Structural Type from a Cultured Soft Coral Sarcophyton glaucum | 作者: | CHANG-FENG DAI | 公開日期: | 2015 | 卷: | 5 | 來源出版物: | Scientific Reports | 摘要: | Glaucumolides A (1) and B (2), novel biscembranes composed of an unprecedented α,β-unsaturated ε-lactone, along with the known metabolites ximaolide A (3) and isosarcophytonolide D (4), were isolated from the cultured soft coral Sarcophyton glaucum. The structures of the new metabolites were determined by extensive spectroscopic analyses. Compounds 1 and 2 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. In anti-inflammation assay, compounds 1 and 2 displayed strong inhibition of superoxide anion generation and elastase release in human neutrophils stimulated by fMLP/CB. Furthermore, both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein, and compounds 1-3 were found to effectively reduce the expression of cyclooxygenase-2 protein, in lipopolysaccharide-stimulated RAW264.7 macrophage cells. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84946601364&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/391673 |
DOI: | 10.1038/srep15624 | SDG/關鍵字: | antiinflammatory agent; antineoplastic agent; cyclooxygenase 2; cytochalasin B; diterpene; glaucumolide A; glaucumolide B; inducible nitric oxide synthase; lactone; lipopolysaccharide; Ptgs2 protein, mouse; superoxide; animal; Anthozoa; biosynthesis; chemistry; drug screening; HL-60 cell line; human; inflammation; isolation and purification; Leukemia, Promyelocytic, Acute; macrophage; metabolism; mouse; neutrophil; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; procedures; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 2; Cytochalasin B; Diterpenes; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Inflammation; Lactones; Leukemia, Promyelocytic, Acute; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitric Oxide Synthase Type II; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Superoxides |
顯示於: | 海洋研究所 |
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