https://scholars.lib.ntu.edu.tw/handle/123456789/391674
Title: | Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta | Authors: | CHANG-FENG DAI | Keywords: | Anti-inflammatory activity; Cladiella hirsuta; Cytotoxic activity; Eunicellins; Soft coral | Issue Date: | 2015 | Journal Volume: | 13 | Journal Issue: | 5 | Start page/Pages: | 2757-2769 | Source: | Marine Drugs | Abstract: | Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. ? 2015 by the authors; licensee MDPI. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84930653674&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/391674 |
DOI: | 10.3390/md13052757 | SDG/Keyword: | 6 alpha hydroxypolyanthellin A; antineoplastic agent; diterpenoid; drug metabolite; elastase; hirsutalin s; hirsutalin t; hirsutalin u; hirsutalin v; superoxide; unclassified drug; antiinflammatory agent; diterpene; eunicellin; pancreatic elastase; antiinflammatory activity; antiproliferative activity; Article; Cladiella hirsuta; controlled study; coral; drug cytotoxicity; drug determination; drug isolation; drug screening; drug structure; human; human cell; animal; Anthozoa; cell proliferation; chemistry; drug effects; metabolism; neutrophil; Alcyonacea; Cladiella; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Proliferation; Diterpenes; Humans; Neutrophils; Pancreatic Elastase; Superoxides |
Appears in Collections: | 海洋研究所 |
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