|Title:||Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults||Authors:||Pau-Chung CHEN
Pau-Chung CHENChen, Pau-Chung
|Issue Date:||Aug-2015||Journal Volume:||241||Journal Issue:||2||Start page/Pages:||657--663||Source:||Atherosclerosis||Abstract:||
Objective: Bisphenol A (BPA) is a chemical produced at high volumes and used widely in food and drink packaging. In adults, elevated BPA concentrations are associated with cardiovascular disease. BPA exposure is plausibly linked to atherosclerosis in adolescents and young adults, but evidence is lacking to date. Methods: We recruited 886 subjects (12-30 years of age) from a population-based sample of adolescents and young adults based on a mass urine screening to determine the relationship between serum levels of BPA and carotid intima-media thickness (CIMT). Results: The geometric mean (standard deviation) of concentrations of BPA were 1.72 (5.5) ng/mL After controlling for confounding factors, linear regression analyzes showed a 1-unit increase in natural log BPA was significantly associated with an increase in mean CIMT (mm) (β=0.005, 95% C.I.=0.003-0.007, p<0.001) and other measurement of CIMT (including right and left side of common carotid artery, carotid bulb and internal carotid artery). Conclusion: Higher serum concentrations of BPA were associated with increased CIMT in this cross-sectional study of adolescents and young adults. Studies to clarify the mechanisms of these associations are needed. ? 2015 Elsevier Ireland Ltd.
|URI:||http://scholars.lib.ntu.edu.tw/handle/123456789/394898||DOI:||10.1016/j.atherosclerosis.2015.06.038||metadata.dc.subject.other:||4,4' isopropylidenediphenol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; 4,4' isopropylidenediphenol; benzhydryl derivative; phenol derivative; plastic; adult; alcohol consumption; anthropometric parameters; arterial wall thickness; Article; atherosclerosis; blood level; cardiovascular risk; carotid artery; child; common carotid artery; container; cross-sectional study; disease marker; female; human; internal carotid artery; male; priority journal; smoking; Taiwan; Taiwanese; triacylglycerol blood level; adolescent; atherosclerosis; blood; carotid artery; drug effects; pathology; risk factor; statistical model; urine; young adult; Adolescent; Adult; Atherosclerosis; Benzhydryl Compounds; Carotid Arteries; Carotid Intima-Media Thickness; Child; Cross-Sectional Studies; Female; Humans; Linear Models; Male; Phenols; Plastics; Risk Factors; Young Adult
|Appears in Collections:||公共衛生學系|
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