Association of STAT6 genetic variants with childhood atopic dermatitis in Taiwanese population
Resource
J. Dermatol. Sci., 79(3), 222-228
Journal
Journal of Dermatological Science
Journal Volume
79
Journal Issue
3
Pages
222-228
Date Issued
2015
Author(s)
YUNG-LING LEE
Lee, Yungling Leo
Yen, Jeffrey Jong-Young
Kuo, Nai-Wei
Su, Ming-Wei
Yang, Ming-Fong
Hsiao, Yu-Ping
Wang, I-Jen
Liu, Fu-Tong
Abstract
Background: Atopic dermatitis (AD) is the single most common allergic disease in children. STAT6 has been noted as a hub molecule in IL-4 mediated response and AD pathogenesis. However, the association between STAT6 genetic variants and childhood AD has never been thoroughly examined. Objective: We investigate the association between STAT6 genetic variants and childhood AD risk in Taiwanese population. Methods: We used data from the Han Chinese in Beijing genome panel of International HapMap Project and the Taiwan Children Health Study cohort to investigate the association of STAT6 genetic variants and childhood AD risks. Four tagged SNPs were selected from HapMap database and rs324011 was most significantly associated with childhood AD. Subsequently, deep sequencing around rs324011 and unconditional/conditional logistic models were applied. Results: rs324011 showed statistical significance for the occurrence of childhood AD (OR: 1.23; 95% CI: 1.01-1.51) and rs167769 showed borderline statistical significance (OR: 1.21; 95% CI: 0.99-1.49). Likelihood ratio tests revealed that haplotypes (rs167769/rs324011) were associated with childhood AD (global p = 0.0018). T alleles of two STAT6 intron2 SNPs, rs324011 and rs167769, increased STAT6 promoter activity significantly in luciferase reporter assay. Conclusion: T allele of rs324011 in STAT6 would increase the risk of AD occurrence in children. Haplotypes of rs324011/rs167769 were also significantly associated with childhood AD in Taiwanese population. ? 2015 Japanese Society for Investigative Dermatology.
Subjects
Atopic dermatitis; Childhood; Genetic variant; Signal transducer and activator of transcription 6; STAT6
SDGs
Other Subjects
STAT6 protein; STAT6 protein; STAT6 protein, human; allele; Article; atopic dermatitis; child; childhood disease; controlled study; disease association; female; gene frequency; gene identification; genetic association; genetic risk; genetic variability; genotype; Han Chinese; haplotype; human; human cell; in vitro study; luciferase assay; major clinical study; male; priority journal; promoter region; school child; single nucleotide polymorphism; STAT6 gene; Taiwanese; adolescent; Asian continental ancestry group; atopic dermatitis; genetic predisposition; genetics; intron; Taiwan; Adolescent; Alleles; Asian Continental Ancestry Group; Child; Dermatitis, Atopic; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Introns; Male; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; STAT6 Transcription Factor; Taiwan
Type
journal article