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  1. NTU Scholars
  2. 醫學院
  3. 分子醫學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/395275
Title: Association of STAT6 genetic variants with childhood atopic dermatitis in Taiwanese population
Authors: YUNG-LING LEE
Lee, Yungling Leo
Yen, Jeffrey Jong-Young
LI-CHUNG HSU 
Kuo, Nai-Wei
Su, Ming-Wei
Yang, Ming-Fong
Hsiao, Yu-Ping
Wang, I-Jen
Liu, Fu-Tong
Keywords: Atopic dermatitis; Childhood; Genetic variant; Signal transducer and activator of transcription 6; STAT6
Issue Date: 2015
Journal Volume: 79
Journal Issue: 3
Start page/Pages: 222-228
Source: Journal of Dermatological Science 
Abstract: 
Background: Atopic dermatitis (AD) is the single most common allergic disease in children. STAT6 has been noted as a hub molecule in IL-4 mediated response and AD pathogenesis. However, the association between STAT6 genetic variants and childhood AD has never been thoroughly examined. Objective: We investigate the association between STAT6 genetic variants and childhood AD risk in Taiwanese population. Methods: We used data from the Han Chinese in Beijing genome panel of International HapMap Project and the Taiwan Children Health Study cohort to investigate the association of STAT6 genetic variants and childhood AD risks. Four tagged SNPs were selected from HapMap database and rs324011 was most significantly associated with childhood AD. Subsequently, deep sequencing around rs324011 and unconditional/conditional logistic models were applied. Results: rs324011 showed statistical significance for the occurrence of childhood AD (OR: 1.23; 95% CI: 1.01-1.51) and rs167769 showed borderline statistical significance (OR: 1.21; 95% CI: 0.99-1.49). Likelihood ratio tests revealed that haplotypes (rs167769/rs324011) were associated with childhood AD (global p = 0.0018). T alleles of two STAT6 intron2 SNPs, rs324011 and rs167769, increased STAT6 promoter activity significantly in luciferase reporter assay. Conclusion: T allele of rs324011 in STAT6 would increase the risk of AD occurrence in children. Haplotypes of rs324011/rs167769 were also significantly associated with childhood AD in Taiwanese population. ? 2015 Japanese Society for Investigative Dermatology.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-84945441204&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/395275
DOI: 10.1016/j.jdermsci.2015.05.006
SDG/Keyword: STAT6 protein; STAT6 protein; STAT6 protein, human; allele; Article; atopic dermatitis; child; childhood disease; controlled study; disease association; female; gene frequency; gene identification; genetic association; genetic risk; genetic variability; genotype; Han Chinese; haplotype; human; human cell; in vitro study; luciferase assay; major clinical study; male; priority journal; promoter region; school child; single nucleotide polymorphism; STAT6 gene; Taiwanese; adolescent; Asian continental ancestry group; atopic dermatitis; genetic predisposition; genetics; intron; Taiwan; Adolescent; Alleles; Asian Continental Ancestry Group; Child; Dermatitis, Atopic; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Introns; Male; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; STAT6 Transcription Factor; Taiwan
[SDGs]SDG3
Appears in Collections:分子醫學研究所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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