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  3. Epidemiology and Preventive Medicine / 流行病學與預防醫學研究所
  4. Association of urine CC16 and lung function and asthma in Chinese children
 
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Association of urine CC16 and lung function and asthma in Chinese children

Journal
Allergy and Asthma Proceedings
Journal Volume
36
Journal Issue
4
Pages
e59-e64
Date Issued
2015
Author(s)
YUNG-LING LEE  
DOI
10.2500/aap.2015.36.3853
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-84938397422&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/395277
Abstract
Background: Many studies have shown the relationship between serum Club cell secretory protein-16 (CC16) and respiratory diseases. However, little research has been done to study urinary CC16 in relation to respiratory diseases. Our objective was to examine the association of urinary CC16 and physician-diagnosed asthma or lung function measurements in Chinese children. Methods: A total of 147 physician-diagnosed children with asthma, ages 9-15 years, were recruited from our cross-sectional study population in northeast China. The 390 healthy children who were not asthmatic and not smokers were selected at random from the population according to 10% proportional sampling. Lung function values, including forced expiratory volume in 1 second and forced vital capacity were measured with two portable spirometers. Urine CC16 was determined by using an enzyme-link immunoassay kit. The relationships between urine CC16 levels and asthma, lung function were assessed by multiple regression models. Results: The geometric mean (95% confidence interval [CI]) creatinine-adjusted urine CC16 level was, for creatinine, 9.77 ng/mg (95% CI, 8.12-12.02 ng/mg). After adjustments for sex, age, body mass index, parental education, and smoking status, lower urine CC16 levels were found to be associated with asthma (odds ratio 0.782 [95% CI, 0.617- 0.990]). A positive association was found between urine CC16 and forced vital capacity (beta 0.064 [95% CI, 0.008-0.119]). Conclusion: Our study demonstrated lower levels of urine CC16 and lung function in patients with asthma than in those patients without asthma. CC16 in urine may be a useful tool or biomarker for investigating lung epithelium integrity among children with asthma or lung injury. Copyright ? 2015, OceanSide Publications, Inc., U.S.A.
SDGs

[SDGs]SDG3

Other Subjects
club cell secretory protein 16; creatinine; unclassified drug; uteroglobin; biological marker; SCGB1A1 protein, human; uteroglobin; adolescent; age; Article; asthma; body mass; child; China; Chinese; controlled study; creatinine urine level; cross-sectional study; educational status; ELISA kit; female; forced expiratory volume; forced vital capacity; human; lung function; major clinical study; male; protein urine level; sex; smoking; spirometer; spirometry; urinalysis; Asian continental ancestry group; asthma; case control study; forced expiratory volume; lung function test; pathophysiology; risk factor; urine; Adolescent; Asian Continental Ancestry Group; Asthma; Biomarkers; Case-Control Studies; Child; China; Female; Forced Expiratory Volume; Humans; Male; Respiratory Function Tests; Risk Factors; Uteroglobin
Type
journal article

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