https://scholars.lib.ntu.edu.tw/handle/123456789/395282
Title: | Environmental tobacco smoke exposure, urine CC-16 levels, and asthma outcomes among Chinese children | Authors: | YUNG-LING LEE | Keywords: | asthma; children; Clara cell secretory protein-16; environmental tobacco smoke exposure | Issue Date: | 2015 | Journal Volume: | 70 | Journal Issue: | 3 | Start page/Pages: | 295-301 | Source: | Allergy: European Journal of Allergy and Clinical Immunology | Abstract: | Background Previous studies have shown the relationship between club cell secretory protein (Clara) (CC-16) and respiratory diseases. However, few studies have explored the associations between urine CC-16 levels and environmental tobacco smoke (ETS) exposure in children. The objective of this study was to evaluate whether ETS exposure is associated with CC-16 when stratified by asthma status. Methods In our study, CC-16 was measured on 537 children aged 9-15 from northeast China in 2011-2012 using the Human Clara Cell Protein ELISA kits. Doctor-diagnosed asthma was defined as having ever been diagnosed with asthma by a physician. The relationship between ETS exposure and urine CC-16 level was assessed using linear regression. Results When stratified by asthma status, a negative association between ETS exposure and urine CC-16 was observed after adjusting for the effects of the related covariates, with an adjusted β coefficient [P value] = -0.31 [0.006] in the first 2 years of life and with an adjusted β coefficient [P value] = -0.68 [0.004] in the first 2 years of life and current. Conclusions Our study shows long-term exposure to ETS was associated with urinary CC-16 among children without asthma. ? 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84964285295&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/395282 |
DOI: | 10.1111/all.12559 | SDG/Keyword: | club cell secretory protein; secretory protein; tobacco smoke; unclassified drug; adolescent; Article; asthma; asthmatic state; child; childhood disease; China; Chinese; cross-sectional study; disease association; ELISA kit; environmental exposure; female; human; long term exposure; major clinical study; male; priority journal; school child; urinalysis |
Appears in Collections: | 流行病學與預防醫學研究所 |
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