|Title:||The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review||Authors:||Chun-Han Hou||Issue Date:||2015||Journal Volume:||2015||Source:||Sarcoma||Abstract:||
Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB). Methods. All patients diagnosed with well-differentiated STS-E between 1998 and 2006 were identified in the NCDB. Patients were stratified by use of surgery alone versus use of adjuvant RT after surgery and analyzed using multivariate analysis, Kaplan-Meier analysis, and propensity matching. Results. 2113 patients with well-differentiated STS-E were identified in the NCDB for inclusion with a mean follow-up time of 74 months. 69% of patients were treated with surgery alone, while 26% were treated with surgery followed by adjuvant RT. Patients undergoing amputation were less likely to receive adjuvant RT. There was no difference in overall survival between patients with well-differentiated STS treated with surgery alone and those patients who received adjuvant RT. Conclusions. In the United States, adjuvant RT is being utilized in a quarter of patients being treated for well-differentiated STS-E. While the use of adjuvant RT may be viewed as a means to facilitate limb salvage, this large national database review confirms no survival benefit, regardless of tumor size or margin status. Copyright ? 2015 Alexander L. Lazarides et al.
|DOI:||10.1155/2015/186581||metadata.dc.subject.other:||adult; aged; cancer adjuvant therapy; cancer radiotherapy; cancer surgery; cancer survival; controlled study; female; follow up; human; limb amputation; limb salvage; limb tumor; long term survival; major clinical study; male; overall survival; priority journal; retrospective study; Review; soft tissue sarcoma; treatment outcome; well differentiated liposarcoma; well differentiated soft tissue sarcoma of the extremity
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.