https://scholars.lib.ntu.edu.tw/handle/123456789/396324
標題: | Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta | 作者: | Huang, C.-Y. Tseng, Y.-J. Chokkalingam, U. Hwang, T.-L. Hsu, C.-H. CHANG-FENG DAI Sung, P.-J. Sheu, J.-H. |
公開日期: | 2016 | 卷: | 79 | 期: | 5 | 起(迄)頁: | 1339-1346 | 來源出版物: | Journal of Natural Products | 摘要: | Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils. ? 2016 The American Chemical Society and American Society of Pharmacognosy. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84971449677&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/396324 |
DOI: | 10.1021/acs.jnatprod.5b01142 | SDG/關鍵字: | antineoplastic agent; cembranoid; cytochalasin B; elastase; formylmethionylleucylphenylalanine; idelalisib; ineleganolide; isoprenoid; n [2 (4 hydroxyphenyl)ethyl] 3 methyldodec 2 enamide; natural product; norcembrene; sinularectin; sinulerectadione; sinulerectol A; sinulerectol B; sinulerectol C; superoxide; unclassified drug; antiinflammatory agent; biological product; cyclooxygenase 2; diterpene; terpene; antiinflammatory activity; antineoplastic activity; Article; cancer cell line; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug structure; enzyme release; heteronuclear multiple bond correlation; human; human cell; IC50; leukocyte activation; nuclear Overhauser effect; proton nuclear magnetic resonance; Sinularia erecta; solvent extraction; X ray crystallography; animal; Anthozoa; chemical structure; chemistry; drug screening; isolation and purification; macrophage; marine biology; metabolism; nuclear magnetic resonance; Animals; Anthozoa; Anti-Inflammatory Agents; Biological Products; Cyclooxygenase 2; Diterpenes; Drug Screening Assays, Antitumor; Humans; Macrophages; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Terpenes |
顯示於: | 海洋研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。