https://scholars.lib.ntu.edu.tw/handle/123456789/396324
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, C.-Y. | en_US |
dc.contributor.author | Tseng, Y.-J. | en_US |
dc.contributor.author | Chokkalingam, U. | en_US |
dc.contributor.author | Hwang, T.-L. | en_US |
dc.contributor.author | Hsu, C.-H. | en_US |
dc.contributor.author | CHANG-FENG DAI | en_US |
dc.contributor.author | Sung, P.-J. | en_US |
dc.contributor.author | Sheu, J.-H. | en_US |
dc.creator | Huang, C.-Y.;Tseng, Y.-J.;Chokkalingam, U.;Hwang, T.-L.;Hsu, C.-H.;Dai, C.-F.;Sung, P.-J.;Sheu, J.-H. | - |
dc.date.accessioned | 2018-09-10T15:32:38Z | - |
dc.date.available | 2018-09-10T15:32:38Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84971449677&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/396324 | - |
dc.description.abstract | Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils. ? 2016 The American Chemical Society and American Society of Pharmacognosy. | - |
dc.language | en | en |
dc.relation.ispartof | Journal of Natural Products | en_US |
dc.source | AH | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antineoplastic agent; cembranoid; cytochalasin B; elastase; formylmethionylleucylphenylalanine; idelalisib; ineleganolide; isoprenoid; n [2 (4 hydroxyphenyl)ethyl] 3 methyldodec 2 enamide; natural product; norcembrene; sinularectin; sinulerectadione; sinulerectol A; sinulerectol B; sinulerectol C; superoxide; unclassified drug; antiinflammatory agent; biological product; cyclooxygenase 2; diterpene; terpene; antiinflammatory activity; antineoplastic activity; Article; cancer cell line; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug structure; enzyme release; heteronuclear multiple bond correlation; human; human cell; IC50; leukocyte activation; nuclear Overhauser effect; proton nuclear magnetic resonance; Sinularia erecta; solvent extraction; X ray crystallography; animal; Anthozoa; chemical structure; chemistry; drug screening; isolation and purification; macrophage; marine biology; metabolism; nuclear magnetic resonance; Animals; Anthozoa; Anti-Inflammatory Agents; Biological Products; Cyclooxygenase 2; Diterpenes; Drug Screening Assays, Antitumor; Humans; Macrophages; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Terpenes | - |
dc.title | Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acs.jnatprod.5b01142 | - |
dc.identifier.scopus | 2-s2.0-84971449677 | - |
dc.identifier.isi | WOS:000377150900015 | - |
dc.relation.pages | 1339-1346 | - |
dc.relation.journalvolume | 79 | - |
dc.relation.journalissue | 5 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0003-2242-5643 | - |
顯示於: | 海洋研究所 |
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