NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV)
Journal
Biomolecular NMR Assignments
Journal Volume
10
Journal Issue
2
Start Page
245
End Page
248
ISSN
18742718
Date Issued
2016-10-01
Author(s)
Abstract
The newly emerging human pathogen, Middle East respiratory syndrome coronavirus (MERS-CoV), contains a macro domain in the highly conserved N-terminal region of non-structural protein 3. Intense research has shown that macro domains bind ADP-ribose and other derivatives, but it still remains intangible about their exact function. In this study we report the preliminary structural analysis through solution NMR spectroscopy of the MERS-CoV macro domain. The near complete NMR assignments of MERS-CoV macro domain provide the basis for subsequent structural and biochemical investigation in the context of protein function.
Subjects
ADP-ribose binding module
MERS-CoV
NMR spectroscopy
Viral macro domain
SDGs
Publisher
Springer Netherlands
Type
journal article