https://scholars.lib.ntu.edu.tw/handle/123456789/397091
Title: | Bioactive steroids from the Formosan soft coral Umbellulifera petasites | Authors: | Huang, C.-Y. Chang, C.-W. Tseng, Y.-J. Lee, J. Sung, P.-J. Su, J.-H. Hwang, T.-L. CHANG-FENG DAI Wang, H.-C. Sheu, J.-H. |
Keywords: | Anti-inflammatory activity; Cytotoxic activity; Soft coral; Steroid; Umbellulifera petasites | Issue Date: | 2016 | Journal Volume: | 14 | Journal Issue: | 10 | Source: | Marine Drugs | Abstract: | Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4-11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1-3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1-11 were also examined to evaluate the anti-inflammatory potential, and 2-4 were shown to exhibit significant activities. ? 2016 by the authors. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84992694446&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/397091 |
DOI: | 10.3390/md14100180 | SDG/Keyword: | 25alpha,8alpha epidioxy 24 methylcholesta 6,22 dien 3beta ol; 5alpha pregna 1,20 dien 3 one; 5alpha pregna 20 en 3 one; 5alpha,8alpha epidioxy 24 methylcholesta 6,22 dien 3beta ol; 5alpha,8alpha epidioxy 24alpha ethylcholesta 6 en 3beta ol; 5alpha,8alpha epidioxy 24alpha ethylcholesta 6,22 dien 3beta ol; 5alpha,8alpha epidioxycholesta 6 en 3beta ol; 5alpha,8alpha epidioxycholesta 6,22 dien 3beta ol; antiinflammatory agent; cytotoxic agent; doxorubicin; elastase; nitric oxide; petasitosterone A; petasitosterone B; petasitosterone C; steroid; superoxide; unclassified drug; antiinflammatory agent; antineoplastic agent; steroid; animal tissue; antiinflammatory activity; Article; biological activity; cancer cell destruction; cancer cell line; carbon nuclear magnetic resonance; cell proliferation; controlled study; coral; cytotoxicity; drug structure; enzyme release; human; human cell; IC50; nonhuman; proton nuclear magnetic resonance; structure analysis; Umbellulifera petasites; animal; Anthozoa; chemistry; drug effects; sea; structure activity relation; Taiwan; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Oceans and Seas; Steroids; Structure-Activity Relationship; Taiwan |
Appears in Collections: | 海洋研究所 |
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