https://scholars.lib.ntu.edu.tw/handle/123456789/397199
標題: | Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: An appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries | 作者: | CHEN-CHUNG LIU | 關鍵字: | brexpiprazole; cariprazine; clinical trials; encenicline; phase III; Schizophrenia; valbenazine | 公開日期: | 2016 | 卷: | 17 | 期: | 7 | 起(迄)頁: | 921-936 | 來源出版物: | Expert Opinion on Pharmacotherapy | 摘要: | Introduction: In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future.Areas covered: Recent (post 2013) phase III clinical trials of schizophrenia-targeted therapies were found in US and EU clinical trial registries. Two hundred fifty-three trials were identified, that included 16 investigational compounds. The antipsychotics brexpiprazole and cariprazine have been approved in the US, and although both are dopamine D2 receptor partial agonists, they differ markedly in their pharmacodynamic profiles. Encenicline and valbenazine are first-in-class candidates for treatment of cognitive impairment associated with schizophrenia (CIAS) and tardive dyskinesia, respectively. Eleven add-on compounds were previously approved for other therapeutic indications and are for the most part being studied at academic medical centers and smaller pharmaceutical companies for negative symptoms and CIAS or for specific populations (comorbidities, antipsychotic-induced obesity).Expert opinion: Promising new agents are emerging for schizophrenia and schizoaffective disorder. In addition to better-tolerated antipsychotics that treat positive symptoms, we could see the arrival of the first effective drug for negative symptoms and CIAS, which would strongly facilitate the ultimate goal of recovery in persons with schizophrenia. ? 2016 Informa UK Limited. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84958741397&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/397199 |
DOI: | 10.1517/14656566.2016.1149164 | SDG/關鍵字: | acetylsalicylic acid; benzoic acid; brexpiprazole; cariprazine; clonidine; dronabinol; encenicline; exendin 4; famotidine; lumateperone; memantine; neuroleptic agent; ondansetron; oxytocin; psychotropic agent; raloxifene; simvastatin; tolcapone; valbenazine; neuroleptic agent; drug approval; drug industry; Europe; human; phase 2 clinical trial (topic); phase 3 clinical trial (topic); psychopharmacotherapy; Review; schizoaffective psychosis; schizophrenia; United States; university hospital; Cognition Disorders; European Union; psychology; Psychotic Disorders; register; schizophrenia; Antipsychotic Agents; Clinical Trials, Phase III as Topic; Cognition Disorders; European Union; Humans; Psychotic Disorders; Registries; Schizophrenia; Schizophrenic Psychology; United States |
顯示於: | 醫學系 |
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