https://scholars.lib.ntu.edu.tw/handle/123456789/397286
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Anbazhagan, R. | en_US |
dc.contributor.author | Su, Y.-A. | en_US |
dc.contributor.author | Tsai, H.-C. | en_US |
dc.contributor.author | Jeng, R.-J. | en_US |
dc.contributor.author | RU-JONG JENG | en_US |
dc.creator | RU-JONG JENG;Jeng, R.-J.;Tsai, H.-C.;Su, Y.-A.;Anbazhagan, R.;RU-JONG JENG | - |
dc.date.accessioned | 2018-09-10T15:34:37Z | - |
dc.date.available | 2018-09-10T15:34:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84955493321&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/397286 | - |
dc.description.abstract | Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core-shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin-lattice relaxation time (T1) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core-shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging. ? 2015 American Chemical Society. | - |
dc.language | en | en |
dc.relation.ispartof | ACS Applied Materials and Interfaces | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | contrast agents; core-shell structure; enhanced T1 value; in vivo imaging enhanced excretion; molybdenum disulfide nanoparticle | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Cardiovascular system; Gadolinium; High resolution transmission electron microscopy; Magnetic materials; Magnetic resonance imaging; Magnetism; Molybdenum compounds; Nanoparticles; Nanostructured materials; Paramagnetism; Physiology; Toxicity; Transmission electron microscopy; Contrast agent; Core shell structure; Enhanced excretion; Enhanced T; Molybdenum disulfide; Shells (structures); chelating agent; contrast medium; disulfide; gadolinium; molybdenum; molybdenum disulfide; nanomaterial; animal; chemistry; drug effects; female; human; Institute for Cancer Research mouse; magnetism; nuclear magnetic resonance imaging; particle size; procedures; signal processing; static electricity; thermodynamics; ultrastructure; umbilical vein endothelial cell; X ray photoelectron spectroscopy; Animals; Chelating Agents; Contrast Media; Disulfides; Female; Gadolinium; Human Umbilical Vein Endothelial Cells; Humans; Magnetic Phenomena; Magnetic Resonance Imaging; Mice, Inbred ICR; Molybdenum; Nanostructures; Particle Size; Photoelectron Spectroscopy; Signal Processing, Computer-Assisted; Static Electricity; Thermodynamics | - |
dc.title | MoS<inf>2</inf>-Gd Chelate Magnetic Nanomaterials with Core-Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acsami.5b09722 | - |
dc.relation.pages | 1827-1835 | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Polymer Science and Engineering | - |
crisitem.author.orcid | 0000-0002-0913-4975 | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 高分子科學與工程學研究所 |
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