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  4. Intratracheal administration of budesonide/surfactant to prevent bronchopulmonary dysplasia
 
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Intratracheal administration of budesonide/surfactant to prevent bronchopulmonary dysplasia

Journal
American Journal of Respiratory and Critical Care Medicine
Journal Volume
193
Journal Issue
1
Pages
86-95
Date Issued
2016
Author(s)
Ni, Hsing-Chang
NI, HSING-CHANG
Yeh, Tsu F.
WU-SHIUN HSIEH  
Liu, Hon-Man
LIU, HON-MAN
Chen, Chung M.
TSENG, MEG MEI-CHIH
Wu, Shou Y.
Tseng, Meg Mei-Chih
Husan, Zahid
Li, Tsai C.
Hsieh, Wu S.
Tsai, Chang H.
Lin, Hung C.
DOI
10.1164/rccm.201505-0861OC
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-84962916225&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/399471
Abstract
Rationale: Bronchopulmonary dysplasia (BPD) is an important complication of mechanical ventilation in preterm infants, and no definite therapy can eliminate this complication. Pulmonary inflammation plays a crucial role in its pathogenesis, and glucocorticoid is one potential therapy to prevent BPD. Objectives: To compare the effect of intratracheal administration of surfactant/budesonide with that of surfactant alone on the incidence of death or BPD. Methods: A clinical trial was conducted in three tertiary neonatal centers in the United States and Taiwan, in which 265 very-low-birth-weight infants with severe respiratory distress syndrome who required mechanical ventilation and inspired oxygen (fraction of inspired oxygen, ?50%) within 4 hours of birth were randomly assigned to one of two groups (131 intervention and 134 control). The intervention infants received surfactant (100 mg/kg) and budesonide (0.25 mg/kg), and the control infants received surfactant only (100 mg/kg), until each infant required inspired O2 at less than 30% or was extubated. Measurements and Main Results: The intervention group had a significantly lower incidence of BPD or death (55 of 131 [42.0%] vs. 89 of 134 [66%]; risk ratio, 0.58; 95% confidence interval, 0.44-0.77; P
Subjects
Bronchopulmonary dysplasia; Budesonide; Respiratory distress syndrome; Surfactant; Very-low-birth-weight infants
SDGs

[SDGs]SDG3

Other Subjects
beractant; budesonide; glucose; interleukin 1; interleukin 6; interleukin 8; surfactant; budesonide; lung surfactant; airway pressure; Apgar score; Article; artificial ventilation; bacteremia; blood pressure; body weight; brain hemorrhage; child; chorioamnionitis; comparative effectiveness; controlled study; cytokine response; disease severity; electrolyte blood level; female; follow up; glucose blood level; human; infant; lung dysplasia; major clinical study; male; multicenter study; necrotizing enterocolitis; neurologic examination; newborn; outcome assessment; oxygen supply; patent ductus arteriosus; physical examination; post hoc analysis; preschool child; priority journal; randomized controlled trial; respiratory distress syndrome; retrolental fibroplasia; sepsis; side effect; Taiwan; United States; very low birth weight; adverse effects; Bronchopulmonary Dysplasia; clinical trial; combination drug therapy; endotracheal intubation; mortality; procedures; Respiratory Distress Syndrome, Newborn; Bronchopulmonary Dysplasia; Budesonide; Drug Therapy, Combination; Female; Humans; Infant, Very Low Birth Weight; Intubation, Intratracheal; Male; Pulmonary Surfactants; Respiration, Artificial; Respiratory Distress Syndrome, Newborn
Type
journal article

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