https://scholars.lib.ntu.edu.tw/handle/123456789/400647
Title: | Anti-inflammatory lobane and prenyleudesmane diterpenoids from the soft coral Lobophytum varium | Authors: | Ahmed, A.F. Teng, W.-T. Huang, C.-Y. CHANG-FENG DAI Hwang, T.-L. Sheu, J.-H. |
Keywords: | Anti-inflammatory activity; Lobane; Lobophytum varium; Prenyleudesmane; Soft coral | Issue Date: | 2017 | Journal Volume: | 15 | Journal Issue: | 10 | Source: | Marine Drugs | Abstract: | New lobane-based diterpenoids lobovarols A-D (1-4) and a prenyleudesmane-type diterpenoid lobovarol E (5) along with seven known related diterpenoids (6-12) were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum varium. Their structures were identified on the basis of multiple spectroscopic analyses and spectral comparison. The absolute configuration at C-16 of the known compound 11 is reported herein for the first time. The anti-inflammatory activities of compounds 1-12 were assessed by measuring their inhibitory effect on N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils. Metabolites 2, 5, and 11 were found to show moderate inhibitory activity on the generation of superoxide anion, while compounds 5, 8, 11, and 12 could effectively suppress elastase release in fMLP/CB-stimulated human neutrophil cells at 10 μM. All of the isolated diterpenoids did not exhibit cytotoxic activity (IC50 > 50 μM) towards a limited panel of cancer cell lines. ? 2017 by the authors. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-85031121541&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/400647 |
DOI: | 10.3390/md15100300 | SDG/Keyword: | 13,15 epoxyloba 8,10,16 trien 18 ol; 17,18 epoxyloba 8,10,13(15) trien 16 ol; antiinflammatory agent; diterpenoid; elastase; fuscol; isofuscol; loba 8,10,13(15) trien 17,18 diol; lobatriene; lobatrienolide; lobovarol A; lobovarol B; lobovarol C; lobovarol D; lobovarol E; superoxide; unclassified drug; antiinflammatory agent; cytochalasin B; diterpene; formylmethionylleucylphenylalanine; pancreatic elastase; antiinflammatory activity; Article; coral; cytotoxicity test; drug isolation; drug structure; enzyme release; human; human cell; IC50; in vitro study; Lobophytum varium; neutrophil; animal; Anthozoa; chemistry; drug effect; metabolism; neoplasm; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Line, Tumor; Cytochalasin B; Diterpenes; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neoplasms; Neutrophils; Pancreatic Elastase; Superoxides |
Appears in Collections: | 海洋研究所 |
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