https://scholars.lib.ntu.edu.tw/handle/123456789/400647
標題: | Anti-inflammatory lobane and prenyleudesmane diterpenoids from the soft coral Lobophytum varium | 作者: | Ahmed, A.F. Teng, W.-T. Huang, C.-Y. CHANG-FENG DAI Hwang, T.-L. Sheu, J.-H. |
關鍵字: | Anti-inflammatory activity; Lobane; Lobophytum varium; Prenyleudesmane; Soft coral | 公開日期: | 2017 | 卷: | 15 | 期: | 10 | 來源出版物: | Marine Drugs | 摘要: | New lobane-based diterpenoids lobovarols A-D (1-4) and a prenyleudesmane-type diterpenoid lobovarol E (5) along with seven known related diterpenoids (6-12) were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum varium. Their structures were identified on the basis of multiple spectroscopic analyses and spectral comparison. The absolute configuration at C-16 of the known compound 11 is reported herein for the first time. The anti-inflammatory activities of compounds 1-12 were assessed by measuring their inhibitory effect on N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils. Metabolites 2, 5, and 11 were found to show moderate inhibitory activity on the generation of superoxide anion, while compounds 5, 8, 11, and 12 could effectively suppress elastase release in fMLP/CB-stimulated human neutrophil cells at 10 μM. All of the isolated diterpenoids did not exhibit cytotoxic activity (IC50 > 50 μM) towards a limited panel of cancer cell lines. ? 2017 by the authors. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-85031121541&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/400647 |
DOI: | 10.3390/md15100300 | SDG/關鍵字: | 13,15 epoxyloba 8,10,16 trien 18 ol; 17,18 epoxyloba 8,10,13(15) trien 16 ol; antiinflammatory agent; diterpenoid; elastase; fuscol; isofuscol; loba 8,10,13(15) trien 17,18 diol; lobatriene; lobatrienolide; lobovarol A; lobovarol B; lobovarol C; lobovarol D; lobovarol E; superoxide; unclassified drug; antiinflammatory agent; cytochalasin B; diterpene; formylmethionylleucylphenylalanine; pancreatic elastase; antiinflammatory activity; Article; coral; cytotoxicity test; drug isolation; drug structure; enzyme release; human; human cell; IC50; in vitro study; Lobophytum varium; neutrophil; animal; Anthozoa; chemistry; drug effect; metabolism; neoplasm; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Line, Tumor; Cytochalasin B; Diterpenes; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neoplasms; Neutrophils; Pancreatic Elastase; Superoxides |
顯示於: | 海洋研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。