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  1. NTU Scholars
  2. 生物資源暨農學院
  3. 食品科技研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/402404
Title: Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene
Authors: Min-Hsiung Pan
Jia-Ching Wu
Chi-Tang Ho
Ching-Shu Lai
MIN-HSIUNG PAN 
Keywords: brown adipose tissue; obesity; pterostilbene; resveratrol; white adipose tissue
Issue Date: Jan-2018
Journal Volume: 44
Journal Issue: 1
Start page/Pages: 50--60
Source: BioFactors 
Abstract: 
Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications. Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies. Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity. Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases. ? 2018 BioFactors, 44(1):50–60, 2018. ? 2018 International Union of Biochemistry and Molecular Biology
URI: https://doi.org/10.1002/biof.1409
http://scholars.lib.ntu.edu.tw/handle/123456789/402404
DOI: 10.1002/biof.1409
SDG/Keyword: pterostilbene; resveratrol; adipocytokine; antiobesity agent; pterostilbene; resveratrol; stilbene derivative; caloric intake; cell cycle; cell function; drug bioavailability; energy expenditure; food intake; human; inflammation; intestine flora; nonhuman; obesity; obesity management; priority journal; Review; signal transduction; thermogenesis; white adipocyte; white adipose tissue; adipocyte; animal; brown adipose tissue; diet therapy; drug effect; energy metabolism; gene expression; genetics; lipid diet; metabolism; obesity; pathology; Adipocytes; Adipokines; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Anti-Obesity Agents; Diet, High-Fat; Energy Metabolism; Gastrointestinal Microbiome; Gene Expression; Humans; Obesity; Signal Transduction; Stilbenes; Thermogenesis
[SDGs]SDG3
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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