Chemoprevention by resveratrol and pterostilbene: Targeting on epigenetic regulation
Journal
BioFactors
Journal Volume
44
Journal Issue
1
Pages
26--35
Date Issued
2018-01
Author(s)
Abstract
Epigenetic mechanisms are essential in regulating normal cellular functions and play an important role during the disease developmental stages. However, aberrant epigenetic mechanisms may lead to pathological consequences such as cancer, neurological disorders, bone and skeletal diseases, cardiovascular dysfunction, and metabolic syndrome. The molecular mechanisms of epigenetic modification include DNA methylation, histone modification (acetylation, methylation and phosphorylation), and microRNAs (miRNAs). Unlike genetic modifications, epigenetic states of genes are reversible and can be altered by certain intrinsic and extrinsic factors. In the past few decades, accumulated evidence shows that dietary phytochemicals with chemopreventive effects are also potent epigenetic regulators. Resveratrol and pterostilbene are stilbenoids, which have been reported to have anti-cancer, anti-inflammatory, anti-lipid, and anti-diabetic properties. Stilbenoids are also reported to improve cardiovascular disease. By altering DNA methylation and histone modification or by modulating miRNA expression, resveratrol, and pterostilbene become potent epigenetic modifiers. In this review, we summarize these studies and underlying mechanisms of resveratrol and pterostilbene and their influence on epigenetic mechanisms. ? 2017 BioFactors, 44(1):26–35, 2018. ? 2017 International Union of Biochemistry and Molecular Biology
Subjects
chemoprevention; epigenetic; pterostilbene; resveratrol
SDGs
Other Subjects
microRNA; pterostilbene; resveratrol; antiinflammatory agent; antineoplastic agent; antioxidant; histone; microRNA; pterostilbene; resveratrol; stilbene derivative; cancer chemotherapy; chemoprophylaxis; DNA methylation; drug effect; drug mechanism; drug targeting; epigenetics; gene expression; gene targeting; genetic regulation; histone modification; human; nonhuman; priority journal; regulatory mechanism; Review; agonists; antagonists and inhibitors; bone disease; cardiovascular disease; chemoprophylaxis; degenerative disease; genetic epigenesis; genetics; metabolism; neoplasm; pathology; protein processing; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Bone Diseases; Cardiovascular Diseases; Chemoprevention; DNA Methylation; Epigenesis, Genetic; Histones; Humans; MicroRNAs; Neoplasms; Neurodegenerative Diseases; Protein Processing, Post-Translational; Stilbenes
Type
journal article
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