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  1. NTU Scholars
  2. 生物資源暨農學院
  3. 食品科技研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/402405
Title: Chemoprevention by resveratrol and pterostilbene: Targeting on epigenetic regulation
Authors: Pei-Sheng Lee
Yi-Shiou Chiou
Chi-Tang Ho
Min-Hsiung Pan
MIN-HSIUNG PAN 
Keywords: chemoprevention; epigenetic; pterostilbene; resveratrol
Issue Date: Jan-2018
Journal Volume: 44
Journal Issue: 1
Start page/Pages: 26--35
Source: BioFactors 
Abstract: 
Epigenetic mechanisms are essential in regulating normal cellular functions and play an important role during the disease developmental stages. However, aberrant epigenetic mechanisms may lead to pathological consequences such as cancer, neurological disorders, bone and skeletal diseases, cardiovascular dysfunction, and metabolic syndrome. The molecular mechanisms of epigenetic modification include DNA methylation, histone modification (acetylation, methylation and phosphorylation), and microRNAs (miRNAs). Unlike genetic modifications, epigenetic states of genes are reversible and can be altered by certain intrinsic and extrinsic factors. In the past few decades, accumulated evidence shows that dietary phytochemicals with chemopreventive effects are also potent epigenetic regulators. Resveratrol and pterostilbene are stilbenoids, which have been reported to have anti-cancer, anti-inflammatory, anti-lipid, and anti-diabetic properties. Stilbenoids are also reported to improve cardiovascular disease. By altering DNA methylation and histone modification or by modulating miRNA expression, resveratrol, and pterostilbene become potent epigenetic modifiers. In this review, we summarize these studies and underlying mechanisms of resveratrol and pterostilbene and their influence on epigenetic mechanisms. ? 2017 BioFactors, 44(1):26–35, 2018. ? 2017 International Union of Biochemistry and Molecular Biology
URI: https://doi.org/10.1002/biof.1401
http://scholars.lib.ntu.edu.tw/handle/123456789/402405
DOI: 10.1002/biof.1401
SDG/Keyword: microRNA; pterostilbene; resveratrol; antiinflammatory agent; antineoplastic agent; antioxidant; histone; microRNA; pterostilbene; resveratrol; stilbene derivative; cancer chemotherapy; chemoprophylaxis; DNA methylation; drug effect; drug mechanism; drug targeting; epigenetics; gene expression; gene targeting; genetic regulation; histone modification; human; nonhuman; priority journal; regulatory mechanism; Review; agonists; antagonists and inhibitors; bone disease; cardiovascular disease; chemoprophylaxis; degenerative disease; genetic epigenesis; genetics; metabolism; neoplasm; pathology; protein processing; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Bone Diseases; Cardiovascular Diseases; Chemoprevention; DNA Methylation; Epigenesis, Genetic; Histones; Humans; MicroRNAs; Neoplasms; Neurodegenerative Diseases; Protein Processing, Post-Translational; Stilbenes
[SDGs]SDG3
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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