|Title:||Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population||Authors:||VIN-CENT WU
Wu, Kwan Dun
|Keywords:||Adenoma; Adult; Age Factors; Aged; Aldosterone; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Hyperaldosteronism; Male; Middle Aged; Neoplasm Proteins; Plasma Membrane Calcium-Transporting ATPases; Prevalence; Sodium-Potassium-Exchanging ATPase; Taiwan; Mutation||Issue Date:||12-Jun-2015||Publisher:||NATURE PUBLISHING GROUP||Journal Volume:||5||Source:||Scientific reports||Abstract:||
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy, and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n=91, 61.5%); including mutations in KCNJ5 (n=88, 59.5%), ATP1A1 (n=2, 1.4%), and ATP2B3 (n=1, 0.7%); however, no mutations in CACNA1D were identified. Mutation-carriers were younger (<0.001), had lower Cyst C (p=0.042), pulse wave velocity (p=0.027), C-reactive protein (p=0.042) and a lower rate of proteinuria (p=0.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p=0.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p=0.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.
|Appears in Collections:||醫學教育暨生醫倫理學科所|
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