|Title:||Familial tendency and risk of nasopharyngeal carcinoma in taiwan: effects of covariates on risk||Authors:||Yu, Kelly J
|Keywords:||carcinoma; cohort studies; herpesvirus 4; human; Adult; Antigens, Viral; Biomarkers, Tumor; Cohort Studies; Deoxyribonucleases; Family; Female; Genetic Predisposition to Disease; Herpesvirus 4, Human; Humans; Immunoglobulin A; Incidence; Male; Middle Aged; Nasopharyngeal Neoplasms; Proportional Hazards Models; Prospective Studies; Registries; Risk Factors; Smoking; Surveys and Questionnaires; Taiwan; Viral Proteins||Issue Date:||1-Feb-2011||Publisher:||OXFORD UNIV PRESS INC||Source:||American journal of epidemiology||Abstract:||
In the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (NPC) of male participants in an NPC multiplex family cohort with that of controls in a community cohort in Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total of 43 incident NPC cases were identified from the 1,019 males in the NPC multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) for the multiplex family cohort compared with the community cohort. In the evaluation of anti-EBV viral capsid antigen immunoglobulin A and anti-EBV deoxyribonuclease, the adjusted hazard ratios were 2.8 (95% CI: 1.3, 6.0) and 15.1 (95% CI: 4.2, 54.1) for those positive for 1 EBV seromarker and positive for both seromarkers, respectively, compared with those negative for both EBV seromarkers. The adjusted hazard ratio was 31.0 (95% CI: 9.7, 98.7) for participants who reported a family history of NPC and who were anti-EBV-seropositive compared with individuals without such a history who were anti-EBV-seronegative. The findings suggest that both family history of NPC and anti-EBV seropositivity are important determinants of subsequent NPC risk and that the effect of family history on NPC risk cannot be fully explained by mediation through EBV serologic responses.
|Appears in Collections:||流行病學與預防醫學研究所|
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