|Title:||Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions||Authors:||Hou, Kuo-Liang
Lai, Eddie Hsiang-Hua
JENNY ZWEI-CHIENG CHANG
|Keywords:||Bone resorption; C-C motif chemokine ligand 2; glutamate; glutaminolysis; hypoxia; inflammation; Animals; Blotting, Western; Cells, Cultured; Disease Progression; Glutaminase; Glutamine; Humans; Macrophages; Osteoblasts; Periapical Periodontitis; Rats; Rats, Sprague-Dawley||Issue Date:||Apr-2017||Publisher:||ELSEVIER SCIENCE INC||Source:||Journal of endodontics||Abstract:||
Recently, we have shown that tissue hypoxia stimulates the progression of periapical lesions by up-regulating glycolysis-dependent apoptosis of osteoblasts. Other facets of hypoxia-induced metabolic reprogramming in disease pathogenesis require further investigation. In this study, we examined the connection between hypoxia-augmented glutamine catabolism in osteoblasts and the development of periapical lesions.
|Appears in Collections:||牙醫學系|
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