|Title:||Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model||Authors:||JUI-CHANG TSAI
|Keywords:||BBB = blood-brain barrier; CCD = charge-coupled device; GLUT1 = glucose transporter 1; ICH = intracerebral hemorrhage; ICP = intracranial pressure; IHC = immunohistochemical; IP = intraperitoneal; PBS = phosphate-buffered saline; PbtO2 = partial pressure of oxygen in the brain tissue; RBC = red blood cell; SAH = subarachnoid hemorrhage; SMA = smooth muscle actin; SVZ = subventricular zone; TBI = traumatic brain injury; aSDH = acute subdural hemorrhage; acute subdural hemorrhage; aspirin; microcirculation; rat model; trauma||Issue Date:||Oct-2018||Publisher:||AMER ASSOC NEUROLOGICAL SURGEONS||Journal Volume:||129||Journal Issue:||4||Start page/Pages:||997-1007||Source:||Journal of neurosurgery||Abstract:||
Direct brain compression and secondary injury due to increased intracranial pressure are believed to be the pathognomic causes of a grave outcome in acute subdural hemorrhage (aSDH). However, ischemic damage from aSDH has received limited attention. The authors hypothesized that cerebral microcirculation is altered after aSDH. Direct visualization of microcirculation was conducted in a novel rat model.
|Appears in Collections:||醫學系|
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