https://scholars.lib.ntu.edu.tw/handle/123456789/407002
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang, C.-H. | en_US |
dc.contributor.author | Chiou, S.-H. | en_US |
dc.contributor.author | Chou, C.-P. | en_US |
dc.contributor.author | Chen, Y.-C. | en_US |
dc.contributor.author | Huang, Y.-J. | en_US |
dc.contributor.author | Peng, C.-A. | en_US |
dc.creator | Peng, C.-A.;Huang, Y.-J.;Chen, Y.-C.;Chiou, S.-H.;Wang, C.-H.;Chou, C.-P. | - |
dc.date.accessioned | 2019-05-09T07:03:04Z | - |
dc.date.available | 2019-05-09T07:03:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/407002 | - |
dc.description.abstract | CD133+ cells in glioblastoma (GBM) display cancer stem cell-like properties and have been considered as the culprit of tumor recurrence, justifying exploration of potential therapeutic modalities targeting CD133+ cancer stem-like cells (CSCs). For photothermolysis studies, GBM-CD133+ and GBM-CD133- cells mixed with various ratios were challenged with single-walled carbon nanotubes (SWNTs) conjugated with CD133 monoclonal antibody (anti-CD133) and then irradiated with near-infrared laser light. Results show that GBM-CD133+ cells were selectively targeted and eradicated, whereas GBM-CD133- cells remained viable. In addition, in vitro tumorigenic and self-renewal capability of GBM-CD133+ treated with localized hyperthermia was significantly blocked. Furthermore, GBM-CD133+ cells pretreated with anti-CD133-SWNTs and irradiated by near-infrared laser 2 days after xenotransplantation in nude mice did not exhibit sustainability of CSC features for tumor growth. Taken altogether, our studies demonstrated that anti-CD133-SWNTs have the potential to be utilized as a thermal-coupling agent to effectively target and destroy GBM CSCs in vitro and in vivo. From the Clinical Editor: Glioblastoma remains one of the most notorious cancer from the standpoint of recurrence and overall resistance to therapy. CD133+ stem cells occur among GBM cells, and may be responsible for the huge recurrence risk. This paper discusses a targeted elimination method of these cells, which may enable more efficient therapy in an effort to minimize or prevent recurrence. ? 2011 Elsevier Inc. | - |
dc.relation.ispartof | Nanomedicine: Nanotechnology, Biology, and Medicine | en_US |
dc.subject | Cancer stem-like cells; CD133; Glioblastoma; Near-infrared laser; Single-walled carbon nanotubes | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Cancer stem-like cells; CD133; Glioblastomas; Near-infrared lasers; Single-walled carbon; Coupling agents; Cryogenic liquids; Cytology; Infrared devices; Laser surgery; Monoclonal antibodies; Single-walled carbon nanotubes (SWCN); Stem cells; Surface plasmon resonance; Tumors; Infrared lasers; antibody conjugate; CD133 antigen; monoclonal antibody; monoclonal antibody CD133; single walled nanotube; unclassified drug; animal experiment; animal model; article; biological therapy; cancer growth; cancer stem cell; cell renewal; cell viability; controlled study; endocytosis; gene expression; glioblastoma; glioblastoma stem like cell; human; human cell; hyperthermic therapy; laser; molecularly targeted therapy; mouse; nonhuman; photolysis; photothermolysis; xenotransplantation; Animals; Antibodies, Monoclonal; Antigens, CD; Glioblastoma; Glycoproteins; Humans; Hyperthermia, Induced; Mice; Mice, Nude; Nanotubes, Carbon; Neoplastic Stem Cells; Peptides; Tumor Cells, Cultured; Mus musculus | - |
dc.title | Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.nano.2010.06.010 | - |
dc.identifier.scopus | 2-s2.0-78751702579 | - |
dc.relation.pages | 69-79 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 1 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Civil Engineering | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 土木工程學系 |
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