https://scholars.lib.ntu.edu.tw/handle/123456789/409846
標題: | Fabrication of multipotent poly-para-xylylene particles in controlled nanoscopic dimensions | 作者: | Yuan R.-H. Li Y.-J. Sun H.-Y. Wu C.-Y. Guan Z.-Y. Ho H.-Y. Fang C.-Y. Chen H.-Y. |
關鍵字: | Dynamic interface;Janus particle;Multifunctional;Nanoparticle;Poly-para-xylylene | 公開日期: | 2016 | 卷: | 139 | 起(迄)頁: | 259-268 | 來源出版物: | Colloids and Surfaces B: Biointerfaces | 摘要: | In this study, poly-. para-xylylene-based multifunctional nanoparticles (PPX-NPs) were fabricated. Based on the solubility characteristics determined for asymmetrically substituted poly-. para-xylylenes in polar solvents, well-dispersed nanocolloids with a controllable size ranging from 50 to 800 nm were produced in solution by the displacement of the solvent (water). These size ranges were found to have acceptable cellular compatibility through examinations of cultured 3T3 fibroblasts and adipose-derived stem cells treated with the PPX-NPs. In addition, these nanoscale PPX-NPs exhibited versatile bioconjugation properties in that a variety of available functional groups can be adopted from their counterpart, thin-film poly-. para-xylylenes, during the production of these nanoparticles. For instance, bifunctional PPX-NPs with maleimide and benzoyl moieties were produced to enable immobilization via a maleimide-thiol reaction concurrent with a photochemical reaction. A cleavable PPX-NP was also produced with a thiol-exchangeable surface property. Additionally, by performing electrohydrodynamic jetting of parallel polymer solutions of selected poly-. para-xylylenes, Janus-type or multicompartment PPX-NPs were created. The PPX-NPs can potentially be used for various biomedical applications such as combined diagnostics and drug delivery, multiplexing of detection, multiple-drug loading, and the targeted delivery of biomolecules or drugs. ? 2015 Elsevier B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/409846 | ISSN: | 09277765 | DOI: | 10.1016/j.colsurfb.2015.12.022 |
顯示於: | 化學工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。