https://scholars.lib.ntu.edu.tw/handle/123456789/409848
Title: | Multifaceted and route-controlled "click" reactions based on vapor-deposited coatings | Authors: | Sun T.-P. Tai C.-H. Wu J.-T. Wu C.-Y. Liang W.-C. Chen H.-Y. |
Issue Date: | 2016 | Journal Volume: | 4 | Journal Issue: | 2 | Start page/Pages: | 265-271 | Source: | Biomaterials Science | Abstract: | "Click" reactions provide precise and reliable chemical transformations for the preparation of functional architectures for biomaterials and biointerfaces. The emergence of a multiple-click reaction strategy has paved the way for a multifunctional microenvironment with orthogonality and precise multitasking that mimics nature. We demonstrate a multifaceted and route-controlled click interface using vapor-deposited functionalized poly-para-xylylenes. Distinctly clickable moieties of ethynyl and maleimide were introduced into poly-para-xylylenes in one step via a chemical vapor deposition (CVD) copolymerization process. The advanced interface coating allows for a double-click route with concurrent copper(i)-catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAC) and the thiol-maleimide click reaction. Additionally, double-click reactions can also be performed in a cascade manner by controlling the initiation route to enable the CuAAC and/or thiol-yne reaction using a mono-functional alkyne-functionalized poly-para-xylylene. The use of multifaceted coatings to create straightforward and orthogonal interface properties with respect to protein adsorption and cell attachment is demonstrated and characterized. ? 2015 The Royal Society of Chemistry. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/409848 | ISSN: | 20474830 | DOI: | 10.1039/c5bm00417a |
Appears in Collections: | 化學工程學系 |
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