https://scholars.lib.ntu.edu.tw/handle/123456789/409878
標題: | Towards multipotent coatings: Chemical vapor deposition and biofunctionalization of carbonyl-substituted copolymers | 作者: | Elkasabi Y. Yoshida M. Nandivada H. Chen H.-Y. Lahann J. |
關鍵字: | Biomaterials;Chemical vapor deposition;Coatings;Immobilization;Surface analysis | 公開日期: | 2008 | 卷: | 29 | 期: | 11 | 起(迄)頁: | 855-870 | 來源出版物: | Macromolecular Rapid Communications | 摘要: | Future advances in designing bioactive materials, such as antithrombotic coatings for cardiovascular stents, will require widely applicable and robust methods of surface modification. In this paper, we report on the development of multifunctional polymer coatings made by chemical vapor deposition (CVD) copolymerization. Polymer coatings of various [2.2]paracyclophane derivatives were co-deposited in controlled ratios and their chemical composition verified by FT-IR and X-ray photoelectron spectroscopy. Furthermore, preliminary biocompatibility of these coatings was assessed using human umbilical vein endothelial cells and 3T3 murine fibroblasts. The parallel immobilization of two different antithrombotic biomolecules onto a CVD-based copolymer is also demonstrated by orthogonal immobilization strategies. ? 2008 WILEY-VCH Verlag GmbH & Co. KGaA. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/409878 | ISSN: | 10221336 | DOI: | 10.1002/marc.200800101 |
顯示於: | 化學工程學系 |
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