情緒記憶中典條件學習與工具條件學習之神經機制探討(3/3)

Abstract

本研究探討依核在抑制行逃避學習中所扮演的角色。研究結果發現學習後操弄終依核內的麩胺酸受體會影響記憶。結果顯示依核與杏仁核及海馬的互動在記憶形成過程中扮演重要角色。

This study examined the role of the amygdala, hippocampus, nucleus accumbens (NAc) in formation and expression of aversive memory. Rats were trainined on an inhibitory avoidance task that contains classical and operant conditioning components with the latter playing a more significantly role. In a two-phase training paradigm of an inhibitory avoidance task, CNQX impaired retention if infused into the dorsal hippocampus during the context training phase, into the amygdala during the shock training phase or into the NAc during either phase. Simultaneous infusion of 0.1 µg CNQX into the amygdala plus NAc or into the hippocampus plus NAc caused no addition of effects. The retention deficit caused by 1.0 µg CNQX infused into the hippocampus or amygdala was attenuated by glutamate infused into the NAc. Infusion of NE into the hippocampus or amygdala enhanced retention, which was blocked by CNQX infused into the NAc. These findings suggest that the NAc is involved in mediating influences from the amygdala and dorsal hippocampus on memory processing in the inhibitory avoidance task.