情緒記憶中典條件學習與工具條件學習之神經機制探討(3/3)
Date Issued
2003
Date
2003
Author(s)
DOI
912413H002020
Abstract
This study examined the role of the
amygdala, hippocampus, nucleus
accumbens (NAc) in formation and
expression of aversive memory. Rats were
trainined on an inhibitory avoidance task
that contains classical and operant
conditioning components with the latter
playing a more significantly role. In a
two-phase training paradigm of an
inhibitory avoidance task, CNQX
impaired retention if infused into the
dorsal hippocampus during the context
training phase, into the amygdala during
the shock training phase or into the NAc
during either phase. Simultaneous
infusion of 0.1 µg CNQX into the
amygdala plus NAc or into the
hippocampus plus NAc caused no
addition of effects. The retention deficit
caused by 1.0 µg CNQX infused into the
hippocampus or amygdala was attenuated
by glutamate infused into the NAc.
Infusion of NE into the hippocampus or
amygdala enhanced retention, which was
blocked by CNQX infused into the NAc.
These findings suggest that the NAc is
involved in mediating influences from the
amygdala and dorsal hippocampus on
memory processing in the inhibitory
avoidance task.
Subjects
依核
杏仁核
海馬
麩胺酸
情緒記憶
大白鼠
Publisher
臺北市：國立臺灣大學心理學系暨研究所
Type
report
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