|Title:||Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide||Authors:||Chen, Chun Ta
Lee, Chen An
|Keywords:||Active pharmaceutical ingredient | Pyridin-4-amine | RESS | Solute solubility | Supercritical carbon dioxide||Issue Date:||1-Mar-2017||Publisher:||ELSEVIER SCI LTD||Journal Volume:||18||Start page/Pages:||173||Source:||Journal of CO2 Utilization||Abstract:||
© 2017 Elsevier Ltd. Graphical abstract: Novel solute solubility data of pyridin-4-amine (C5H6N2, also known as 4-aminopyridine or fampridine) in supercritical carbon dioxide are measured in this study. This compound is an active pharmaceutical ingredient (API) for the treatment of neurological disorder, and the Alzheimer’s disease. The solubility data at three isotherms (308.2, 318.2 and 328.2K) are reported for pressures from 10 to 22MPa. These solubility results are ranged from 2×10−5 to 2×10−4mol fraction, and are confirmed as thermodynamically consistent. We further apply the rapid expansion of supercritical solution (RESS) process to micronize this API. At our optimal operation condition, the original API with a mean particle size of 532.3±236.5μm is micronized to 0.32±0.07μm. The RESS processed products are much more uniform and nearly spherical amorphous particles. Finally, an in vitro dissolution test illustrates an enhanced dissolution rate by 2.9 times for the micronized pyridin-4-amine.
|Appears in Collections:||化學工程學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.