https://scholars.lib.ntu.edu.tw/handle/123456789/410335
Title: | Trifunctional Fe 3 O 4 /CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy | Authors: | Wang Y.-P. Liao Y.-T. Liu C.-H. Yu J. Alamri H.R. Alothman Z.A. Hossain M.S.A. Yamauchi Y. Wu K.C.-W. |
Keywords: | bladder cancer;controlled release;core-shell-corona nanoparticles;magnetic guidance;targeting | Issue Date: | 2017 | Journal Volume: | 3 | Journal Issue: | 10 | Start page/Pages: | 2366-2374 | Source: | ACS Biomaterials Science and Engineering | Abstract: | Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe 3 O 4 ) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe 3 O 4 /CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe 3 O 4 /CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe 3 O 4 /CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems. ? 2017 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/410335 | ISSN: | 23739878 | DOI: | 10.1021/acsbiomaterials.7b00230 | SDG/Keyword: | Biocompatibility; Chemotherapy; Diseases; Iron research; Magnetism; Nanoparticles; Nanostructures; Particle size; Shells (structures); Synthesis (chemical); Bladder cancer cells; Bladder cancers; Controlled release; Core shell; Drug delivery system; Surface functionalities; Targeted chemotherapy; targeting; Nanomagnetics; alginic acid; arginylglycylaspartic acid; calcium phosphate; doxorubicin; superparamagnetic iron oxide nanoparticle; Article; biocompatibility; bladder cancer; cancer chemotherapy; controlled study; drug delivery system; drug efficacy; drug release; drug targeting; human; human cell; magnetic field; particle size; pH; priority journal; reaction optimization; surface property; T24 cell line; target cell |
Appears in Collections: | 化學工程學系 |
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