https://scholars.lib.ntu.edu.tw/handle/123456789/410734
Title: | Fabrication of photothermo-responsive drug-loaded nanogel for synergetic cancer therapy | Authors: | Chang R. Tsai W.-B. |
Keywords: | Anti-cancer;Drug delivery;N-isopropylacrylamide;Nanogel;Photothermo-responsive;Sodium copper chlorophyllin | Issue Date: | 2018 | Journal Volume: | 10 | Journal Issue: | 10 | Source: | Polymers | Abstract: | Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment. ? 2018 by the authors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/410734 | ISSN: | 20734360 | DOI: | 10.3390/polym10101098 | SDG/Keyword: | Acrylic monomers; Amides; Diseases; Drug delivery; Nanostructured materials; Oncology; Targeted drug delivery; Anti-cancer; N- isopropylacrylamide; Nanogels; Photothermo-responsive; Sodium copper chlorophyllin; Controlled drug delivery |
Appears in Collections: | 化學工程學系 |
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